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10.1097/MOP.0000000000000227 http://scihub22266oqcxt.onion/10.1097/MOP.0000000000000227 C4466102!4466102!25888154     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Pediatr 2015 ; 27 (3): 341-7 Nephropedia Template TP {{tp|p=25888154|t=2015. Cellular Mechanisms of Alveolar Pathology in Childhood Interstitial Lung Diseases: Current Insights from Mouse Genetics |pdf=|usr=}}{{25888154}} gab.com Text Cellular Mechanisms of Alveolar Pathology in Childhood Interstitial Lung Diseases: Current Insights from Mouse Genetics JO: Curr Opin Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=25888154 #FOAvip Purpose of Review: Childhood Interstitial Lung Diseases (ILDs) are a diverse class of disorders affecting the alveolar gas exchange region that lack specific treatments and are usually fatal. Here, we integrate recent insights into alveolar cell biology with histopathology from well-characterized mutations of surfactant-associated genes. We take a reductionist approach by parsing discrete histological features and correlating each to perturbation of a particular function of the alveolar epithelial type 2 (AT2) cell, the central driver of disease, in order to generate a working model for the cellular mechanisms of disease pathogenesis. Recent Findings: The application of genetically modified mice and single cell genomics has yielded new insights into lung biology, including the identification of a bipotent alveolar progenitor in development, mapping of adult AT2 stem cells in vivo, and demonstration that latent cooperative interactions with fibroblasts can be pathologically activated by targeted injury of the AT2 cell. Summary: As we learn more about individual and cooperative roles for alveolar cells in health, we can dissect how perturbations of specific cellular functions contribute to disease in childhood ILDs. We hope our updated model centered around the AT2 cell as the initiator of disease provides a cellular framework that researchers can build upon and revise as they identify the specific molecular signals within and between alveolar cells that mediate the diverse pathologic features, so that targeted pharmacologic and cell-based treatments for patients can ultimately be engineered. Twit Text FOAVip Cellular Mechanisms of Alveolar Pathology in Childhood Interstitial Lung Diseases: Current Insights from Mouse Genetics ????Curr Opin Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=25888154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25888154 #FOAvip English Wikipedia <ref>{{Cite pmid|25888154}}</ref> Cellular Mechanisms of Alveolar Pathology in Childhood Interstitial Lung Diseases: Current Insights from Mouse Genetics #MMPMID25888154 Kuo CS; Desai TJ Curr Opin Pediatr 2015[Jun]; 27 (3): 341-7 PMID25888154show ga Purpose of Review: Childhood Interstitial Lung Diseases (ILDs) are a diverse class of disorders affecting the alveolar gas exchange region that lack specific treatments and are usually fatal. Here, we integrate recent insights into alveolar cell biology with histopathology from well-characterized mutations of surfactant-associated genes. We take a reductionist approach by parsing discrete histological features and correlating each to perturbation of a particular function of the alveolar epithelial type 2 (AT2) cell, the central driver of disease, in order to generate a working model for the cellular mechanisms of disease pathogenesis. Recent Findings: The application of genetically modified mice and single cell genomics has yielded new insights into lung biology, including the identification of a bipotent alveolar progenitor in development, mapping of adult AT2 stem cells in vivo, and demonstration that latent cooperative interactions with fibroblasts can be pathologically activated by targeted injury of the AT2 cell. Summary: As we learn more about individual and cooperative roles for alveolar cells in health, we can dissect how perturbations of specific cellular functions contribute to disease in childhood ILDs. We hope our updated model centered around the AT2 cell as the initiator of disease provides a cellular framework that researchers can build upon and revise as they identify the specific molecular signals within and between alveolar cells that mediate the diverse pathologic features, so that targeted pharmacologic and cell-based treatments for patients can ultimately be engineered. äCellular Mechanisms of Alveolar Pathology in Childhood Interstitial Lu(epmc).pdf DeepDyve Pubget Overpricing