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10.4155/fmc.14.60 http://scihub22266oqcxt.onion/10.4155/fmc.14.60 C4465542!4465542!25163000     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Med+Chem 2014 ; 6 (11): 1265-90 Nephropedia Template TP {{tp|p=25163000|t=2014. The essential roles of chemistry in high-throughput screening triage |pdf=|usr=}}{{25163000}} gab.com Text The essential roles of chemistry in high-throughput screening triage JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25163000 #FOAvip It is increasingly clear that academic high-throughput screening (HTS) and virtual HTS triage suffers from a lack of scientists trained in the art and science of early drug discovery chemistry. Many recent publications report the discovery of compounds by screening that are most likely artifacts or promiscuous bioactive compounds, and these results are not placed into the context of previous studies. For HTS to be most successful, it is our contention that there must exist an early partnership between biologists and medicinal chemists. Their combined skill sets are necessary to design robust assays and efficient workflows that will weed out assay artifacts, false positives, promiscuous bioactive compounds and intractable screening hits, efforts that ultimately give projects a better chance at identifying truly useful chemical matter. Expertise in medicinal chemistry, cheminformatics and purification sciences (analytical chemistry) can enhance the post-HTS triage process by quickly removing these problematic chemotypes from consideration, while simultaneously prioritizing the more promising chemical matter for follow-up testing. It is only when biologists and chemists collaborate effectively that HTS can manifest its full promise. Twit Text FOAVip The essential roles of chemistry in high-throughput screening triage ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25163000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25163000 #FOAvip English Wikipedia <ref>{{Cite pmid|25163000}}</ref> The essential roles of chemistry in high-throughput screening triage #MMPMID25163000 Dahlin JL; Walters MA Future Med Chem 2014[Jul]; 6 (11): 1265-90 PMID25163000show ga It is increasingly clear that academic high-throughput screening (HTS) and virtual HTS triage suffers from a lack of scientists trained in the art and science of early drug discovery chemistry. Many recent publications report the discovery of compounds by screening that are most likely artifacts or promiscuous bioactive compounds, and these results are not placed into the context of previous studies. For HTS to be most successful, it is our contention that there must exist an early partnership between biologists and medicinal chemists. Their combined skill sets are necessary to design robust assays and efficient workflows that will weed out assay artifacts, false positives, promiscuous bioactive compounds and intractable screening hits, efforts that ultimately give projects a better chance at identifying truly useful chemical matter. Expertise in medicinal chemistry, cheminformatics and purification sciences (analytical chemistry) can enhance the post-HTS triage process by quickly removing these problematic chemotypes from consideration, while simultaneously prioritizing the more promising chemical matter for follow-up testing. It is only when biologists and chemists collaborate effectively that HTS can manifest its full promise. äThe essential roles of chemistry in high-throughput screening triage (epmc).pdf DeepDyve Pubget Overpricing