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2015 ; 31
(3
): 352-5
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gab.com Text
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English Wikipedia
Exploring the Relationship Between Serum and Urinary Free Light Chain Levels
During the Different Phases of Renal Damage in Multiple Myeloma Patients
#MMPMID26085720
Xu ZL
; Wu C
; Teng WH
; Wan K
; Jia WJ
; Li HJ
; Meng L
; Zhou JF
; Tang Y
Indian J Hematol Blood Transfus
2015[Sep]; 31
(3
): 352-5
PMID26085720
show ga
The objective was to explore the relationship between the levels of serum and
urinary free light chains (FLCs) during the progression of renal damage in
multiple myeloma (MM) patients. We examined 91 cases of MM patients, detected
levels of serum FLCs (sFLCs), urinary FLCs (uFLCs), and serum creatinine at the
same time, and then compared sFLC and uFLC levels during normal and abnormal
serum creatinine phases. Among the 91 MM patients, 22 patients had abnormal serum
creatinine levels (no uremia), and 69 patients had normal serum creatinine
levels. The levels of sFLCs and uFLCs in patients with abnormal serum creatinine
were beyond normal, namely both serum and urine positive (serum+ and urine+), and
the average concentrations of ?FLCs and ?FLCs were 516.76 and 604.67 mg/L,
respectively. Of the 69 patients with normal creatinine levels, there were 39 and
30 cases of ?-type and ?-type MM, respectively. Of the ?-type patients, 11 cases
were serum positive and urine negative (serum+ and urine-) with an average
concentration of 55.47 mg/L, and 28 cases were serum positive and urine positive
(serum+ and urine+) with an average concentration of 513.09 mg/L. Of the ?-type
patients, 16 cases were serum positive and urine negative (serum+ and urine-)
with an average concentration of 78.44 mg/L, and 14 cases were serum positive and
urine positive (serum+ and urine+) with an average concentration of 518.08 mg/L.
The levels of uFLCs did not parallel those of sFLCs. In addition to sFLC levels,
renal function affected uFLC concentrations. As MM progressed, the concentration
of sFLCs increased in a step-by-step manner, and the uFLCs changed from negative
to positive to negative again. Therefore, the whole progression included three
phases: sserum+ and urine-, serum+ and urine+, and then serum+ and urine-.