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10.3109/08916934.2010.530627 http://scihub22266oqcxt.onion/10.3109/08916934.2010.530627 C4465387!4465387!21231893     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autoimmunity 2011 ; 44 (3): 211-8 Nephropedia Template TP {{tp|p=21231893|t=2011. SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells |pdf=|usr=}}{{21231893}} gab.com Text SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells JO: Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=21231893 #FOAvip The CD28 co-stimulatory pathway is well established for T cell activation. However, there is evidence suggesting the existence of additional co-stimulatory pathways. Here we report that a member of the SLAM superfamily, SLAMF6, or CD352 plays an important role in T cell co-stimulation. Cross-linking of SLAMF6 with anti-CD3 primes human T cell to secrete Th1 cytokines. Among the T cell subsets, CD8+ and CD3+CD4?CD8? cells display the highest Th1 production responses. Engagement of SLAMF6 mobilizes the modulation of the same set of NF-?B-associated genes. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production. Our results suggest the existence of an additional co-stimulatory pathway in human T cells, which is defective in SLE T cells. Twit Text FOAVip SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells ????Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=21231893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21231893 #FOAvip English Wikipedia <ref>{{Cite pmid|21231893}}</ref> SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells #MMPMID21231893 Chatterjee M; Kis-Toth K; Thai TH; Terhorst C; Tsokos GC Autoimmunity 2011[May]; 44 (3): 211-8 PMID21231893show ga The CD28 co-stimulatory pathway is well established for T cell activation. However, there is evidence suggesting the existence of additional co-stimulatory pathways. Here we report that a member of the SLAM superfamily, SLAMF6, or CD352 plays an important role in T cell co-stimulation. Cross-linking of SLAMF6 with anti-CD3 primes human T cell to secrete Th1 cytokines. Among the T cell subsets, CD8+ and CD3+CD4?CD8? cells display the highest Th1 production responses. Engagement of SLAMF6 mobilizes the modulation of the same set of NF-?B-associated genes. Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production. Our results suggest the existence of an additional co-stimulatory pathway in human T cells, which is defective in SLE T cells. äSLAMF6-driven co-stimulation of human peripheral T cells is defective (epmc).pdf DeepDyve Pubget Overpricing