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10.14800/ics.146

http://scihub22266oqcxt.onion/10.14800/ics.146
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C4465365!4465365!26082933
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suck abstract from ncbi


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pmid26082933      Inflamm+Cell+Signal 2014 ; 1 (4): ä
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  • Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity #MMPMID26082933
  • Zhang J; Liu Q; Langdon WY
  • Inflamm Cell Signal 2014[]; 1 (4): ä PMID26082933show ga
  • Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.
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