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10.2174/2213235X113019990004 http://scihub22266oqcxt.onion/10.2174/2213235X113019990004 C4465192!4465192!26078917     free     free     free       Curr+Metabolomics 2013 ; 1 (3): 191-209 Nephropedia Template TP {{tp|p=26078917|t=2013. NMR Metabolomics Analysis of Parkinson s Disease |pdf=|usr=}}{{26078917}} gab.com Text NMR Metabolomics Analysis of Parkinson s Disease JO: Curr Metabolomics http://www.kidney.de/pget.php?&tw=1&pmid=26078917 #FOAvip Parkinson's disease (PD) is a neurodegenerative disease, which is characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta. Although mitochondrial dysfunction and oxidative stress are linked to PD pathogenesis, its etiology and pathology remain to be elucidated. Metabolomics investigates metabolite changes in biofluids, cell lysates, tissues and tumors in order to correlate these metabolomic changes to a disease state. Thus, the application of metabolomics to investigate PD provides a systematic approach to understand the pathology of PD, to identify disease biomarkers, and to complement genomics, transcriptomics and proteomics studies. This review will examine current research into PD mechanisms with a focus on mitochondrial dysfunction and oxidative stress. Neurotoxin-based PD animal models and the rationale for metabolomics studies in PD will also be discussed. The review will also explore the potential of NMR metabolomics to address important issues related to PD treatment and diagnosis. Twit Text FOAVip NMR Metabolomics Analysis of Parkinson s Disease ????Curr Metabolomics http://www.kidney.de/pget.php?&tw=1&pmid=26078917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26078917 #FOAvip English Wikipedia <ref>{{Cite pmid|26078917}}</ref> NMR Metabolomics Analysis of Parkinson s Disease #MMPMID26078917 Lei S; Powers R Curr Metabolomics 2013[]; 1 (3): 191-209 PMID26078917show ga Parkinson's disease (PD) is a neurodegenerative disease, which is characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta. Although mitochondrial dysfunction and oxidative stress are linked to PD pathogenesis, its etiology and pathology remain to be elucidated. Metabolomics investigates metabolite changes in biofluids, cell lysates, tissues and tumors in order to correlate these metabolomic changes to a disease state. Thus, the application of metabolomics to investigate PD provides a systematic approach to understand the pathology of PD, to identify disease biomarkers, and to complement genomics, transcriptomics and proteomics studies. This review will examine current research into PD mechanisms with a focus on mitochondrial dysfunction and oxidative stress. Neurotoxin-based PD animal models and the rationale for metabolomics studies in PD will also be discussed. The review will also explore the potential of NMR metabolomics to address important issues related to PD treatment and diagnosis. äNMR Metabolomics Analysis of Parkinson s Disease (epmc).pdf DeepDyve Pubget Overpricing