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2015 ; 54
(ä): 141-7
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gab.com Text
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Advancing research on endocrine disrupting chemicals in breast cancer: Expert
panel recommendations
#MMPMID25549947
Teitelbaum SL
; Belpoggi F
; Reinlib L
Reprod Toxicol
2015[Jul]; 54
(ä): 141-7
PMID25549947
show ga
Breast cancer incidence continues to increase in the US and Europe, a reflection
of the growing influence of environment factors that interact with personal
genetics. The US Environmental Protection Agency estimates that there are
approximately 10,000 endocrine disrupting chemicals among the common daily
exposures that could affect the risk of disease. The daunting tasks of
identifying, characterizing, and elucidating the mechanisms of endocrine
disrupting chemicals in breast cancer need to be addressed to produce a
comprehensive model that will facilitate preventive strategies and public policy.
An expert panel met to describe and bring attention to needs linking common
environmental exposures, critical windows of exposure, and optimal times of
assessment in investigating breast cancer risk. The group included investigators
with extensive experience in the use of rodent models and in leading population
studies and produced a set of recommendations for effective approaches to gaining
insights into the environmental origins of breast cancer across the lifespan.