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10.1016/j.ccell.2015.04.009 http://scihub22266oqcxt.onion/10.1016/j.ccell.2015.04.009 C4464909!4464909!25982816     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25982816&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2015 ; 27 (6): 809-21 Nephropedia Template TP {{tp|p=25982816|t=2015. The TGF? Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone |pdf=|usr=}}{{25982816}} gab.com Text The TGF Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25982816 #FOAvip Transforming growth factor-? (TGF?) regulates the expression of genes supporting breast cancer cell in bone but little is known about prostate cancer bone metastases and TGF?. Our study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases. TGF? upregulates in prostate cancer cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1. In patients, PMEPA1 expression decreased in metastatic prostate cancer and low Pmepa1 correlated with decreased metastasis-free survival. Only membrane-anchored isoforms of PMEPA1 interacted with R-SMADs and ubiquitin ligases, blocking TGF? signaling independently of the proteasome. Interrupting this negative feedback loop by PMEPA1 knockdown increased prometastatic gene expression and bone metastases in a mouse prostate cancer model. Twit Text FOAVip The TGF Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25982816 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25982816 #FOAvip English Wikipedia <ref>{{Cite pmid|25982816}}</ref> The TGF? Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone #MMPMID25982816 Fournier PG; Juárez P; Jiang G; Clines GA; Niewolna M; Kim HS; Walton HW; Peng CXH; Liu Y; Mohammad KS; Wells CD; Chirgwin JM; Guise TA Cancer Cell 2015[Jun]; 27 (6): 809-21 PMID25982816show ga Transforming growth factor-? (TGF?) regulates the expression of genes supporting breast cancer cell in bone but little is known about prostate cancer bone metastases and TGF?. Our study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases. TGF? upregulates in prostate cancer cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1. In patients, PMEPA1 expression decreased in metastatic prostate cancer and low Pmepa1 correlated with decreased metastasis-free survival. Only membrane-anchored isoforms of PMEPA1 interacted with R-SMADs and ubiquitin ligases, blocking TGF? signaling independently of the proteasome. Interrupting this negative feedback loop by PMEPA1 knockdown increased prometastatic gene expression and bone metastases in a mouse prostate cancer model. äThe TGF? Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metasta(epmc).pdf DeepDyve Pubget Overpricing