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10.1177/0148607113486006 http://scihub22266oqcxt.onion/10.1177/0148607113486006 C4464759!4464759!23609773     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JPEN+J+Parenter+Enteral+Nutr 2014 ; 38 (1): 20-8 Nephropedia Template TP {{tp|p=23609773|t=2014. Parenteral Fish Oil Lipid Emulsions in the Critically Ill: a Systematic Review and Meta-analysis |pdf=|usr=}}{{23609773}} gab.com Text Parenteral Fish Oil Lipid Emulsions in the Critically Ill: a Systematic Review and Meta-analysis JO: JPEN J Parenter Enteral Nutr http://www.kidney.de/pget.php?&tw=1&pmid=23609773 #FOAvip Introduction: Polyunsaturated series-3 fatty acids (PUFAs n-3) contained in fish oils (FO) posess major anti-inflammatory, anti-oxidant, and immunological properties which could be beneficial during critical illness. We hypothesized that parenteral FO containing emulsions may improve clinical outcomes in the critically ill. Methods: We searched computerized databases from 1980 to 2012. We included randomized controlled trials (RCTs) conducted in critically ill adults patients that evaluated FO containing emulsions, either in the context of parenteral nutrition (PN) or enteral nutrition (EN) fed patients. Results: A total of 6 RCTs (n=390 patients) were included; the mean methodological score of all trials was 10 (range: 6?13). When the results of these studies were aggregated, FO containing emulsions were associated with with a trend towards a reduction in mortality (risk ratio RR= 0.71, 95% confidence intervals CI 0.49, 1.04, P=0.08, heterogeneity I2=0%) and a tendency to reduce the duration of mechanical ventilation (weighted mean difference in days [WMD] ?1.41, 95% CI ?3.43, 0.61, P=0.17). However, this strategy had no effect on infections (RR= 0.76, 95% CI 0.42, 1.36, P= 0.35) and intensive care unit (ICU) length of stay (LOS) (WMD ?0.46, 95% CI ?4.87, 3.95, P=0.84, heterogeneity I2=75%). Conclusion: FO containing lipid emulsions may be able to decrease mortality and ventilation days in the critically ill. However, because of the paucity of clinical data, there is inadequate evidence to recommend the routine use of parenteral FO. Large, rigorously designed, RCTs are required to elucidate the efficacy of parenteral FO in the critically ill. Twit Text FOAVip Parenteral Fish Oil Lipid Emulsions in the Critically Ill: a Systematic Review and Meta-analysis ????JPEN J Parenter Enteral Nutr http://www.kidney.de/pget.php?&tw=1&pmid=23609773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23609773 #FOAvip English Wikipedia <ref>{{Cite pmid|23609773}}</ref> Parenteral Fish Oil Lipid Emulsions in the Critically Ill: a Systematic Review and Meta-analysis #MMPMID23609773 Manzanares W; Dhaliwal R; Jurewitsch B; Stapleton RD; Jeejeebhoy KN; Heyland DK JPEN J Parenter Enteral Nutr 2014[Jan]; 38 (1): 20-8 PMID23609773show ga Introduction: Polyunsaturated series-3 fatty acids (PUFAs n-3) contained in fish oils (FO) posess major anti-inflammatory, anti-oxidant, and immunological properties which could be beneficial during critical illness. We hypothesized that parenteral FO containing emulsions may improve clinical outcomes in the critically ill. Methods: We searched computerized databases from 1980 to 2012. We included randomized controlled trials (RCTs) conducted in critically ill adults patients that evaluated FO containing emulsions, either in the context of parenteral nutrition (PN) or enteral nutrition (EN) fed patients. Results: A total of 6 RCTs (n=390 patients) were included; the mean methodological score of all trials was 10 (range: 6?13). When the results of these studies were aggregated, FO containing emulsions were associated with with a trend towards a reduction in mortality (risk ratio RR= 0.71, 95% confidence intervals CI 0.49, 1.04, P=0.08, heterogeneity I2=0%) and a tendency to reduce the duration of mechanical ventilation (weighted mean difference in days [WMD] ?1.41, 95% CI ?3.43, 0.61, P=0.17). However, this strategy had no effect on infections (RR= 0.76, 95% CI 0.42, 1.36, P= 0.35) and intensive care unit (ICU) length of stay (LOS) (WMD ?0.46, 95% CI ?4.87, 3.95, P=0.84, heterogeneity I2=75%). Conclusion: FO containing lipid emulsions may be able to decrease mortality and ventilation days in the critically ill. However, because of the paucity of clinical data, there is inadequate evidence to recommend the routine use of parenteral FO. Large, rigorously designed, RCTs are required to elucidate the efficacy of parenteral FO in the critically ill. äParenteral Fish Oil Lipid Emulsions in the Critically Ill: a Systemati(epmc).pdf DeepDyve Pubget Overpricing