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10.1007/s00134-013-2999-4 http://scihub22266oqcxt.onion/10.1007/s00134-013-2999-4 C4464672!4464672!23812404     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Intensive+Care+Med 2013 ; 39 (10): 1683-94 Nephropedia Template TP {{tp|p=23812404|t=2013. Alternative Lipid Emulsions in the Critically Ill: A Systematic Review of the Evidence |pdf=|usr=}}{{23812404}} gab.com Text Alternative Lipid Emulsions in the Critically Ill: A Systematic Review of the Evidence JO: Intensive Care Med http://www.kidney.de/pget.php?&tw=1&pmid=23812404 #FOAvip Introduction: Parenteral lipid emulsions (LEs) are commonly rich in long-chain triglycerides (LCT) derived from soybean oil (SO). SO containing emulsions may promote systemic inflammation and therefore may adversely affect clinical outcomes. We hypothesized that alternative oil-based LEs (SO-sparing strategies) may improve clinical outcomes in critically ill adult patients compared to SO emulsion only products. The purpose of this systematic review was to evaluate the effect of parenteral SO-sparing strategies on clinical outcomes in intensive care unit (ICU) patients. Methods: We searched computerized databases from 1980 to 2013. We included randomized controlled trials (RCTs) conducted in critically ill adult patients that evaluated SO-sparing strategies versus SO-based LEs in the context of parenteral nutrition (PN). Results: A total of 12 RCTs met inclusion criteria. When the results of these RCTs that were statistically aggregated, SO-sparing strategies were associated with clinically important reductions in mortality (risk ratio RR= 0.83, 95% confidence intervals CI 0.62, 1.11, P = 0.20), in duration of ventilation (weighted mean difference, WMD ?2.57, 95% CI ?5.51, 0.37, P= 0.09), and in ICU length of stay (WMD ?2.31, 95% CI ?5.28, 0.66, P= 0.13) but none of these differences were statistically significant. SO-sparing strategies had no effect on infectious complications (RR=1.13, 95% CI 0.87, 1.46, P=0.35). Conclusion: Alternative oil-based LEs may be associated with clinically important reductions in mortality, duration of ventilation, and ICU LOS but lack of statistical precision precludes any clinical recommendations at this time. Further research is warranted to confirm these potential positive treatment effects. Twit Text FOAVip Alternative Lipid Emulsions in the Critically Ill: A Systematic Review of the Evidence ????Intensive Care Med http://www.kidney.de/pget.php?&tw=1&pmid=23812404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23812404 #FOAvip English Wikipedia <ref>{{Cite pmid|23812404}}</ref> Alternative Lipid Emulsions in the Critically Ill: A Systematic Review of the Evidence #MMPMID23812404 Manzanares W; Dhaliwal R; Jurewitsch B; Stapleton RD; Jeejeebhoy KN; Heyland DK Intensive Care Med 2013[Oct]; 39 (10): 1683-94 PMID23812404show ga Introduction: Parenteral lipid emulsions (LEs) are commonly rich in long-chain triglycerides (LCT) derived from soybean oil (SO). SO containing emulsions may promote systemic inflammation and therefore may adversely affect clinical outcomes. We hypothesized that alternative oil-based LEs (SO-sparing strategies) may improve clinical outcomes in critically ill adult patients compared to SO emulsion only products. The purpose of this systematic review was to evaluate the effect of parenteral SO-sparing strategies on clinical outcomes in intensive care unit (ICU) patients. Methods: We searched computerized databases from 1980 to 2013. We included randomized controlled trials (RCTs) conducted in critically ill adult patients that evaluated SO-sparing strategies versus SO-based LEs in the context of parenteral nutrition (PN). Results: A total of 12 RCTs met inclusion criteria. When the results of these RCTs that were statistically aggregated, SO-sparing strategies were associated with clinically important reductions in mortality (risk ratio RR= 0.83, 95% confidence intervals CI 0.62, 1.11, P = 0.20), in duration of ventilation (weighted mean difference, WMD ?2.57, 95% CI ?5.51, 0.37, P= 0.09), and in ICU length of stay (WMD ?2.31, 95% CI ?5.28, 0.66, P= 0.13) but none of these differences were statistically significant. SO-sparing strategies had no effect on infectious complications (RR=1.13, 95% CI 0.87, 1.46, P=0.35). Conclusion: Alternative oil-based LEs may be associated with clinically important reductions in mortality, duration of ventilation, and ICU LOS but lack of statistical precision precludes any clinical recommendations at this time. Further research is warranted to confirm these potential positive treatment effects. äAlternative Lipid Emulsions in the Critically Ill: A Systematic Review(epmc).pdf DeepDyve Pubget Overpricing