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http://scihub22266oqcxt.onion/ C4464508!4464508!26417328     free     free     free       EXCLI+J 2014 ; 13 (ä): 1131-44 Nephropedia Template TP {{tp|p=26417328|t=2014. Immune mediated liver failure |pdf=|usr=}}{{26417328}} gab.com Text Immune mediated liver failure JO: EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=26417328 #FOAvip Liver failure is a clinical syndrome of various etiologies, manifesting as jaundice, encephalopathy, coagulopathy and circulatory dysfunction, which result in subsequent multiorgan failure. Clinically, liver failure is classified into four categories: acute, subacute, acute-on-chronic and chronic liver failure. Massive hepatocyte death is considered to be the core event in the development of liver failure, which occurs when the extent of hepatocyte death is beyond the liver regenerative capacity. Direct damage and immune-mediated liver injury are two major factors involved in this process. Increasing evidence has suggested the essential role of immune-mediated liver injury in the pathogenesis of liver failure. Here, we review the evolved concepts concerning the mechanisms of immune-mediated liver injury in liver failure from human and animal studies. Both innate and adaptive immunity, especially the interaction of various immune cells and molecules as well as death receptor signaling system are discussed. In addition, we highlight the concept of ?immune coagulation?, which has been shown to be related to the disease progression and liver injury exacerbation in HBV related acute-on-chronic liver failure. Twit Text FOAVip Immune mediated liver failure ????EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=26417328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26417328 #FOAvip English Wikipedia <ref>{{Cite pmid|26417328}}</ref> Immune mediated liver failure #MMPMID26417328 Wang X; Ning Q EXCLI J 2014[]; 13 (ä): 1131-44 PMID26417328show ga Liver failure is a clinical syndrome of various etiologies, manifesting as jaundice, encephalopathy, coagulopathy and circulatory dysfunction, which result in subsequent multiorgan failure. Clinically, liver failure is classified into four categories: acute, subacute, acute-on-chronic and chronic liver failure. Massive hepatocyte death is considered to be the core event in the development of liver failure, which occurs when the extent of hepatocyte death is beyond the liver regenerative capacity. Direct damage and immune-mediated liver injury are two major factors involved in this process. Increasing evidence has suggested the essential role of immune-mediated liver injury in the pathogenesis of liver failure. Here, we review the evolved concepts concerning the mechanisms of immune-mediated liver injury in liver failure from human and animal studies. Both innate and adaptive immunity, especially the interaction of various immune cells and molecules as well as death receptor signaling system are discussed. In addition, we highlight the concept of ?immune coagulation?, which has been shown to be related to the disease progression and liver injury exacerbation in HBV related acute-on-chronic liver failure. äImmune mediated liver failure (epmc).pdf DeepDyve Pubget Overpricing