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10.3892/mmr.2015.3596 http://scihub22266oqcxt.onion/10.3892/mmr.2015.3596 C4464439!4464439!25872931     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med+Rep 2015 ; 12 (2): 1631-8 Nephropedia Template TP {{tp|p=25872931|t=2015. Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis |pdf=|usr=}}{{25872931}} gab.com Text Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25872931 #FOAvip The present study aimed to investigate the effects of aldosterone on vascular endothelial cells and the viability of poly (ADP-ribose) polymerase 1 (PARP1) in cells, and to examine the molecular mechanisms underlying the effects of aldosterone on vascular endothelial cell injury. Cultured endothelial cells were treated either with different concentrations of aldosterone for the same duration or with the same concentrations of aldosterone for different durations, and the levels of apoptosis and activity of PARP1 in the cells were detected, respectively. Aldosterone receptor antagonists or PARP1 inhibitors were added to cells during treatment with aldosterone and the levels of apoptosis and activity of PARP1 were detected. As the concentration of aldosterone increased or the treatment time increased, the number of apoptotic cells and the activity of PARP1 increased. The aldosterone receptor antagonists and PARP1 inhibitors inhibited the increase of apoptosis and PARP1 activity caused by aldosterone treatment. Aldosterone activated the activity of PARP1 via the aldosterone receptor, inhibiting cell proliferation and inducing apoptosis. Treatment with PARP1 may be used as a target for vascular diseases caused by aldosterone at high concentrations. Twit Text FOAVip Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=25872931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25872931 #FOAvip English Wikipedia <ref>{{Cite pmid|25872931}}</ref> Effect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-induced apoptosis #MMPMID25872931 QIAO W; ZHANG W; SHAO S; GAI Y; ZHANG M Mol Med Rep 2015[Aug]; 12 (2): 1631-8 PMID25872931show ga The present study aimed to investigate the effects of aldosterone on vascular endothelial cells and the viability of poly (ADP-ribose) polymerase 1 (PARP1) in cells, and to examine the molecular mechanisms underlying the effects of aldosterone on vascular endothelial cell injury. Cultured endothelial cells were treated either with different concentrations of aldosterone for the same duration or with the same concentrations of aldosterone for different durations, and the levels of apoptosis and activity of PARP1 in the cells were detected, respectively. Aldosterone receptor antagonists or PARP1 inhibitors were added to cells during treatment with aldosterone and the levels of apoptosis and activity of PARP1 were detected. As the concentration of aldosterone increased or the treatment time increased, the number of apoptotic cells and the activity of PARP1 increased. The aldosterone receptor antagonists and PARP1 inhibitors inhibited the increase of apoptosis and PARP1 activity caused by aldosterone treatment. Aldosterone activated the activity of PARP1 via the aldosterone receptor, inhibiting cell proliferation and inducing apoptosis. Treatment with PARP1 may be used as a target for vascular diseases caused by aldosterone at high concentrations. äEffect and mechanism of poly (ADP-ribose) polymerase-1 in aldosterone-(epmc).pdf DeepDyve Pubget Overpricing