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Hydra as a tractable, long-lived model system for senescence #MMPMID26136619
Bellantuono AJ; Bridge D; Martínez DE
Invertebr Reprod Dev 2015[Jan]; 59 (sup1): 39-44 PMID26136619show ga
Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast, Hydra oligactis can be experimentally induced to undergo reproduction-associated senescence. This provides a powerful comparative system for future studies.