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The EU(7)-PIM list: a list of potentially inappropriate medications for older
people consented by experts from seven European countries
#MMPMID25967540
Renom-Guiteras A
; Meyer G
; Thürmann PA
Eur J Clin Pharmacol
2015[Jul]; 71
(7
): 861-75
PMID25967540
show ga
PURPOSE: The aim of the study was to develop a European list of potentially
inappropriate medications (PIM) for older people, which can be used for the
analysis and comparison of prescribing patterns across European countries and for
clinical practice. METHODS: A preliminary PIM list was developed, based on the
German PRISCUS list of potentially inappropriate medications and other PIM lists
from the USA, Canada and France. Thirty experts on geriatric prescribing from
Estonia, Finland, France, the Netherlands, Spain and Sweden participated; eight
experts performed a structured expansion of the list, suggesting further
medications; twenty-seven experts participated in a two-round Delphi survey
assessing the appropriateness of drugs and suggesting dose adjustments and
therapeutic alternatives. Finally, twelve experts completed a brief final survey
to decide upon issues requiring further consensus. RESULTS: Experts reached a
consensus that 282 chemical substances or drug classes from 34 therapeutic groups
are PIM for older people; some PIM are restricted to a certain dose or duration
of use. The PIM list contains suggestions for dose adjustments and therapeutic
alternatives. CONCLUSIONS: The European Union (EU)(7)-PIM list is a screening
tool, developed with participation of experts from seven European countries, that
allows identification and comparison of PIM prescribing patterns for older people
across European countries. It can also be used as a guide in clinical practice,
although it does not substitute the decision-making process of individualised
prescribing for older people. Further research is needed to investigate the
feasibility and applicability and, finally, the clinical benefits of the newly
developed list.
|*Potentially Inappropriate Medication List
[MESH]
|Age Factors
[MESH]
|Consensus
[MESH]
|Delphi Technique
[MESH]
|Dose-Response Relationship, Drug
[MESH]
|Drug Administration Schedule
[MESH]
|Drug Dosage Calculations
[MESH]
|Drug Substitution
[MESH]
|Drug-Related Side Effects and Adverse Reactions/prevention & control
[MESH]
|Europe
[MESH]
|Geriatrics/*methods
[MESH]
|Humans
[MESH]
|Inappropriate Prescribing/*prevention & control
[MESH]
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