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10.1155/2015/479703 http://scihub22266oqcxt.onion/10.1155/2015/479703 C4464004!4464004!26106627     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol+Res 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26106627|t=2015. Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |pdf=|usr=}}{{26106627}} gab.com Text Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26106627 #FOAvip In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. The liver can induce the conversion of naïve CD4+ T cells to CD4+ regulatory T cells and induce tolerance to locally expressed antigens. This tolerance mechanism is carefully regulated in physiological conditions but any imbalance could be pathological. An overly tolerant immune response can lead to chronic infections while an overreactive and unbridled immune response can lead to autoimmune hepatitis. With the recent advent of monoclonal antibodies able to target regulatory T cells (daclizumab) and improve immune responses and several ongoing clinical trials analysing the impact of regulatory T cell infusion on autoimmune liver disease or liver transplant tolerance, modulation of immunological tolerance through CD4+ regulatory T cells could be a key element of future immunotherapies for several liver diseases allowing restoring the balance between proper immune responses and tolerance. ? Twit Text FOAVip Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26106627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26106627 #FOAvip English Wikipedia <ref>{{Cite pmid|26106627}}</ref> Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis #MMPMID26106627 Lapierre P; Lamarre A J Immunol Res 2015[]; 2015 (ä): ä PMID26106627show ga In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. The liver can induce the conversion of naïve CD4+ T cells to CD4+ regulatory T cells and induce tolerance to locally expressed antigens. This tolerance mechanism is carefully regulated in physiological conditions but any imbalance could be pathological. An overly tolerant immune response can lead to chronic infections while an overreactive and unbridled immune response can lead to autoimmune hepatitis. With the recent advent of monoclonal antibodies able to target regulatory T cells (daclizumab) and improve immune responses and several ongoing clinical trials analysing the impact of regulatory T cell infusion on autoimmune liver disease or liver transplant tolerance, modulation of immunological tolerance through CD4+ regulatory T cells could be a key element of future immunotherapies for several liver diseases allowing restoring the balance between proper immune responses and tolerance. ? äRegulatory T Cells in Autoimmune and Viral Chronic Hepatitis (epmc).pdf DeepDyve Pubget Overpricing