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10.1080/07924259.2014.963713 http://scihub22266oqcxt.onion/10.1080/07924259.2014.963713 C4463993!4463993!26136621     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Invertebr+Reprod+Dev 2015 ; 59 (sup1): 51-8 Nephropedia Template TP {{tp|p=26136621|t=2015. Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster |pdf=|usr=}}{{26136621}} gab.com Text Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster JO: Invertebr Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=26136621 #FOAvip The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the exterior and interior milieus, is critically impacted by dietary, environmental, and inflammatory conditions that influence health and lifespan. Work in flies is now uncovering the multifaceted molecular mechanisms that control homeostasis in this tissue, and establishing its central role in health and lifespan of metazoans. The Drosophila intestine has thus emerged as a productive, genetically accessible model to study various aspects of the pathophysiology of aging. Studies in flies have characterized the maintenance of regenerative homeostasis, the development of immune senescence, the loss of epithelial barrier function, the decline in metabolic homeostasis, as well as the maintenance of epithelial diversity in this tissue. Due to its fundamental similarity to vertebrate intestines, it can be anticipated that findings obtained in this system will have important implications for our understanding of age-related changes in the human intestine. Here, I review recent studies exploring age-related changes in the fly intestine, and their insight into the regulation of health and lifespan of the animal. Twit Text FOAVip Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster ????Invertebr Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=26136621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26136621 #FOAvip English Wikipedia <ref>{{Cite pmid|26136621}}</ref> Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster #MMPMID26136621 Jasper H Invertebr Reprod Dev 2015[Jan]; 59 (sup1): 51-8 PMID26136621show ga The gastrointestinal tract, due to its role as a digestive organ and as a barrier between the exterior and interior milieus, is critically impacted by dietary, environmental, and inflammatory conditions that influence health and lifespan. Work in flies is now uncovering the multifaceted molecular mechanisms that control homeostasis in this tissue, and establishing its central role in health and lifespan of metazoans. The Drosophila intestine has thus emerged as a productive, genetically accessible model to study various aspects of the pathophysiology of aging. Studies in flies have characterized the maintenance of regenerative homeostasis, the development of immune senescence, the loss of epithelial barrier function, the decline in metabolic homeostasis, as well as the maintenance of epithelial diversity in this tissue. Due to its fundamental similarity to vertebrate intestines, it can be anticipated that findings obtained in this system will have important implications for our understanding of age-related changes in the human intestine. Here, I review recent studies exploring age-related changes in the fly intestine, and their insight into the regulation of health and lifespan of the animal. äExploring the physiology and pathology of aging in the intestine of Dr(epmc).pdf DeepDyve Pubget Overpricing