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10.3390/ijms160511196 http://scihub22266oqcxt.onion/10.3390/ijms160511196 C4463696!4463696 !25993291     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25993291 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (5 ): 11196-212 Nephropedia Template TP {{tp|p=25993291 |t=2015. Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms |pdf=|usr=}}{{25993291 }} gab.com Text Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25993291 #FOAvip Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies. The results confirmed the microarray results. Two different members of the NK pathway, HCST and GRZB, which act at different steps in the NK-pathway, were actively transcribed and translated into proteins in the same cells in the AAA tissue demonstrated by double staining. Furthermore, double staining with antibodies against CD68 or CD8 together with HCST, TYROBP, PTK2B or PLCG2 revealed that CD68 and CD8 positive cells expressed proteins of the NK-pathway but were not the only inflammatory cells involved in the NK-pathway in the AAA tissue. The results provide strong evidence that the NK Cell Mediated Cytotoxicity Pathway is activated in human AAA and valuable insight for future studies to dissect the pathogenesis of human AAA. Twit Text FOAVip Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25993291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25993291 #FOAvip English Wikipedia <ref>{{Cite pmid|25993291 }}</ref> Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms #MMPMID25993291 Hinterseher I ; Schworer CM ; Lillvis JH ; Stahl E ; Erdman R ; Gatalica Z ; Tromp G ; Kuivaniemi H Int J Mol Sci 2015[May]; 16 (5 ): 11196-212 PMID25993291 show ga Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies. The results confirmed the microarray results. Two different members of the NK pathway, HCST and GRZB, which act at different steps in the NK-pathway, were actively transcribed and translated into proteins in the same cells in the AAA tissue demonstrated by double staining. Furthermore, double staining with antibodies against CD68 or CD8 together with HCST, TYROBP, PTK2B or PLCG2 revealed that CD68 and CD8 positive cells expressed proteins of the NK-pathway but were not the only inflammatory cells involved in the NK-pathway in the AAA tissue. The results provide strong evidence that the NK Cell Mediated Cytotoxicity Pathway is activated in human AAA and valuable insight for future studies to dissect the pathogenesis of human AAA. |Adaptor Proteins, Signal Transducing/genetics/metabolism [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, Myelomonocytic/metabolism [MESH] |Aorta, Abdominal/metabolism/pathology [MESH] |Aortic Aneurysm, Abdominal/immunology/metabolism/*pathology [MESH] |CD8 Antigens/metabolism [MESH] |Female [MESH] |Focal Adhesion Kinase 2/genetics/metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Killer Cells, Natural/cytology/immunology/*metabolism [MESH] |Male [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Middle Aged [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Phospholipase C gamma/metabolism [MESH] |Proto-Oncogene Proteins c-vav/genetics/metabolism [MESH] |Receptors, Immunologic/genetics/metabolism [MESH]Immunohistochemical analysis of the natural killer cell cytotoxicity p(epmc).pdf DeepDyve Pubget Overpricing