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2015 ; 16
(5
): 11131-77
Nephropedia Template TP
gab.com Text
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English Wikipedia
Imaging of small animal peripheral artery disease models: recent advancements and
translational potential
#MMPMID25993289
Lin JB
; Phillips EH
; Riggins TE
; Sangha GS
; Chakraborty S
; Lee JY
; Lycke RJ
; Hernandez CL
; Soepriatna AH
; Thorne BR
; Yrineo AA
; Goergen CJ
Int J Mol Sci
2015[May]; 16
(5
): 11131-77
PMID25993289
show ga
Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms
of arterial disease outside of the heart. As such, PAD development is a
multifactorial process with a variety of manifestations. For example, aneurysms
are pathological expansions of an artery that can lead to rupture, while ischemic
atherosclerosis reduces blood flow, increasing the risk of claudication, poor
wound healing, limb amputation, and stroke. Current PAD treatment is often
ineffective or associated with serious risks, largely because these disorders are
commonly undiagnosed or misdiagnosed. Active areas of research are focused on
detecting and characterizing deleterious arterial changes at early stages using
non-invasive imaging strategies, such as ultrasound, as well as emerging
technologies like photoacoustic imaging. Earlier disease detection and
characterization could improve interventional strategies, leading to better
prognosis in PAD patients. While rodents are being used to investigate PAD
pathophysiology, imaging of these animal models has been underutilized. This
review focuses on structural and molecular information and disease progression
revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular
disease models in mice, rats, and rabbits. Effective translation to humans
involves better understanding of underlying PAD pathophysiology to develop novel
therapeutics and apply non-invasive imaging techniques in the clinic.