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10.3390/ijms160511013 http://scihub22266oqcxt.onion/10.3390/ijms160511013 C4463688!4463688!25988383     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (5): 11013-33 Nephropedia Template TP {{tp|p=25988383|t=2015. The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation |pdf=|usr=}}{{25988383}} gab.com Text The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25988383 #FOAvip Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and the presence of anti-nuclear antibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. B and T lymphocyte abnormalities, dysregulation of apoptosis, defects in the clearance of apoptotic materials, and various genetic and epigenetic factors are attributed to the development of SLE. The latest research findings point to the association between abnormal epigenetic regulation and SLE, which has attracted considerable interest worldwide. It is the purpose of this review to present and discuss the relationship between aberrant epigenetic regulation and SLE, including DNA methylation, histone modifications and microRNAs in patients with SLE, the possible mechanisms of immune dysfunction caused by epigenetic changes, and to better understand the roles of aberrant epigenetic regulation in the initiation and development of SLE and to provide an insight into the related therapeutic options in SLE. Twit Text FOAVip The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25988383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25988383 #FOAvip English Wikipedia <ref>{{Cite pmid|25988383}}</ref> The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation #MMPMID25988383 Wu H; Zhao M; Chang C; Lu Q Int J Mol Sci 2015[May]; 16 (5): 11013-33 PMID25988383show ga Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and the presence of anti-nuclear antibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. B and T lymphocyte abnormalities, dysregulation of apoptosis, defects in the clearance of apoptotic materials, and various genetic and epigenetic factors are attributed to the development of SLE. The latest research findings point to the association between abnormal epigenetic regulation and SLE, which has attracted considerable interest worldwide. It is the purpose of this review to present and discuss the relationship between aberrant epigenetic regulation and SLE, including DNA methylation, histone modifications and microRNAs in patients with SLE, the possible mechanisms of immune dysfunction caused by epigenetic changes, and to better understand the roles of aberrant epigenetic regulation in the initiation and development of SLE and to provide an insight into the related therapeutic options in SLE. äThe Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic (epmc).pdf DeepDyve Pubget Overpricing