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10.3390/ijms160510526 http://scihub22266oqcxt.onion/10.3390/ijms160510526 C4463660!4463660!26006224     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (5): 10526-36 Nephropedia Template TP {{tp|p=26006224|t=2015. Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid ?-Mediated Neurotoxicity |pdf=|usr=}}{{26006224}} gab.com Text Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid -Mediated Neurotoxicity JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26006224 #FOAvip Alzheimer?s disease (AD) is characterized by a large number of amyloid-? (A?) deposits in the brain. Therefore, inhibiting A? aggregation or destabilizing preformed aggregates could be a promising therapeutic target for halting/slowing the progression of AD. Chitosan oligosaccharides (COS) have previously been reported to exhibit antioxidant and neuroprotective effects. Recent study shows that COS could markedly decrease oligomeric A?-induced neurotoxicity and oxidative stress in rat hippocampal neurons. However, the potential mechanism that COS reduce A?-mediated neurotoxicity remains unclear. In the present study, our findings from circular dichroism spectroscopy, transmission electron microscope and thioflavin T fluorescence assay suggested that COS act as an inhibitor of A? aggregation and this effect shows dose-dependency. Moreover, data from thioflavin T assay indicated that COS could significantly inhibit fibrils formation and disrupt preformed fibrils in a dose-dependent manner. Furthermore, the addition of COS attenuated A?1-42-induced neurotoxicity in rat cortical neurons. Taken together, our results demonstrated for the first time that COS could inhibit A?1-42 fibrils formation and disaggregate preformed fibrils, suggesting that COS may have anti-A? fibrillogenesis and fibril-destabilizing properties. These findings highlight the potential role of COS as novel therapeutic agents for the prevention and treatment of AD. Twit Text FOAVip Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid -Mediated Neurotoxicity ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26006224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26006224 #FOAvip English Wikipedia <ref>{{Cite pmid|26006224}}</ref> Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid ?-Mediated Neurotoxicity #MMPMID26006224 Dai X; Hou W; Sun Y; Gao Z; Zhu S; Jiang Z Int J Mol Sci 2015[May]; 16 (5): 10526-36 PMID26006224show ga Alzheimer?s disease (AD) is characterized by a large number of amyloid-? (A?) deposits in the brain. Therefore, inhibiting A? aggregation or destabilizing preformed aggregates could be a promising therapeutic target for halting/slowing the progression of AD. Chitosan oligosaccharides (COS) have previously been reported to exhibit antioxidant and neuroprotective effects. Recent study shows that COS could markedly decrease oligomeric A?-induced neurotoxicity and oxidative stress in rat hippocampal neurons. However, the potential mechanism that COS reduce A?-mediated neurotoxicity remains unclear. In the present study, our findings from circular dichroism spectroscopy, transmission electron microscope and thioflavin T fluorescence assay suggested that COS act as an inhibitor of A? aggregation and this effect shows dose-dependency. Moreover, data from thioflavin T assay indicated that COS could significantly inhibit fibrils formation and disrupt preformed fibrils in a dose-dependent manner. Furthermore, the addition of COS attenuated A?1-42-induced neurotoxicity in rat cortical neurons. Taken together, our results demonstrated for the first time that COS could inhibit A?1-42 fibrils formation and disaggregate preformed fibrils, suggesting that COS may have anti-A? fibrillogenesis and fibril-destabilizing properties. These findings highlight the potential role of COS as novel therapeutic agents for the prevention and treatment of AD. äChitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate A(epmc).pdf DeepDyve Pubget Overpricing