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10.3390/ijms16059557 http://scihub22266oqcxt.onion/10.3390/ijms16059557 C4463604!4463604!25927578     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (5): 9557-72 Nephropedia Template TP {{tp|p=25927578|t=2015. miRNAs in the Pathogenesis of Systemic Lupus Erythematosus |pdf=|usr=}}{{25927578}} gab.com Text miRNAs in the Pathogenesis of Systemic Lupus Erythematosus JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25927578 #FOAvip MicroRNAs (miRNAs) were first discovered as regulatory RNAs that controlled the timing of the larval development of Caenorhabditis elegans. Since then, nearly 30,000 mature miRNA products have been found in many species, including plants, warms, flies and mammals. Currently, miRNAs are well established as endogenous small (~22 nt) noncoding RNAs, which have functions in regulating mRNA stability and translation. Owing to intensive investigations during the last decade, miRNAs were found to play essential roles in regulating many physiological and pathological processes. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by elevated autoantibodies against nuclear antigens and excessive inflammatory responses affecting multiple organs. Although efforts were taken and theories were produced to elucidate the pathogenesis of SLE, we still lack sufficient knowledge about the disease for developing effective therapies for lupus patients. Recent advances indicate that miRNAs are involved in the development of SLE, which gives us new insights into the pathogenesis of SLE and might lead to the finding of new therapeutic targets. Here, we will review recent discoveries about how miRNAs are involved in the pathogenesis of SLE and how it can promote the development of new therapy. Twit Text FOAVip miRNAs in the Pathogenesis of Systemic Lupus Erythematosus ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25927578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25927578 #FOAvip English Wikipedia <ref>{{Cite pmid|25927578}}</ref> miRNAs in the Pathogenesis of Systemic Lupus Erythematosus #MMPMID25927578 Qu B; Shen N Int J Mol Sci 2015[May]; 16 (5): 9557-72 PMID25927578show ga MicroRNAs (miRNAs) were first discovered as regulatory RNAs that controlled the timing of the larval development of Caenorhabditis elegans. Since then, nearly 30,000 mature miRNA products have been found in many species, including plants, warms, flies and mammals. Currently, miRNAs are well established as endogenous small (~22 nt) noncoding RNAs, which have functions in regulating mRNA stability and translation. Owing to intensive investigations during the last decade, miRNAs were found to play essential roles in regulating many physiological and pathological processes. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by elevated autoantibodies against nuclear antigens and excessive inflammatory responses affecting multiple organs. Although efforts were taken and theories were produced to elucidate the pathogenesis of SLE, we still lack sufficient knowledge about the disease for developing effective therapies for lupus patients. Recent advances indicate that miRNAs are involved in the development of SLE, which gives us new insights into the pathogenesis of SLE and might lead to the finding of new therapeutic targets. Here, we will review recent discoveries about how miRNAs are involved in the pathogenesis of SLE and how it can promote the development of new therapy. ämiRNAs in the Pathogenesis of Systemic Lupus Erythematosus (epmc).pdf DeepDyve Pubget Overpricing