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10.4103/0301-4738.158070

http://scihub22266oqcxt.onion/10.4103/0301-4738.158070
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C4463555!4463555!26044470
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suck abstract from ncbi


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pmid26044470      Indian+J+Ophthalmol 2015 ; 63 (4): 318-22
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  • Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy #MMPMID26044470
  • Venkatesh P; Gogia V; Gupta S; Tayade A; Shilpy N; Shah BM; Guleria R
  • Indian J Ophthalmol 2015[Apr]; 63 (4): 318-22 PMID26044470show ga
  • Purpose:: To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC). Methods:: Patients with acute macular SC with lesions threatening and/or involving fovea were enrolled. All patients received CyP (1 g/m2 ) for 3 days followed by high-dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects. Results:: Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13?40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1-year was 0.31 ± 0.23 (P ? 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect. Conclusion:: Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.
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