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10.1074/jbc.M114.633560 http://scihub22266oqcxt.onion/10.1074/jbc.M114.633560 C4463471!4463471 !25925952     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25925952 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Endoplasmic Reticulum Stress Sensor IRE1? in Intestinal Epithelial Cells Is Essential for Protecting against Colitis |pdf=|usr=}}{{25925952 }} gab.com Text The Endoplasmic Reticulum Stress Sensor IRE1 in Intestinal Epithelial Cells Is Essential for Protecting against Colitis JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25925952 #FOAvip Intestinal epithelial cells (IECs) have critical roles in maintaining homeostasis of intestinal epithelium. Endoplasmic reticulum (ER) stress is implicated in intestinal epithelium homeostasis and inflammatory bowel disease; however, it remains elusive whether IRE1?, a major sensor of ER stress, is directly involved in these processes. We demonstrate here that genetic ablation of Ire1? in IECs leads to spontaneous colitis in mice. Deletion of IRE1? in IECs results in loss of goblet cells and failure of intestinal epithelial barrier function. IRE1? deficiency induces cell apoptosis through induction of CHOP, the pro-apoptotic protein, and sensitizes cells to lipopolysaccharide, an endotoxin from bacteria. IRE1? deficiency confers upon mice higher susceptibility to chemical-induced colitis. These results suggest that IRE1? functions to maintain the intestinal epithelial homeostasis and plays an important role in defending against inflammation bowel diseases. Twit Text FOAVip The Endoplasmic Reticulum Stress Sensor IRE1 in Intestinal Epithelial Cells Is Essential for Protecting against Colitis ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25925952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25925952 #FOAvip English Wikipedia <ref>{{Cite pmid|25925952 }}</ref> The Endoplasmic Reticulum Stress Sensor IRE1? in Intestinal Epithelial Cells Is Essential for Protecting against Colitis #MMPMID25925952 Zhang HS ; Chen Y ; Fan L ; Xi QL ; Wu GH ; Li XX ; Yuan TL ; He SQ ; Yu Y ; Shao ML ; Liu Y ; Bai CG ; Ling ZQ ; Li M ; Liu Y ; Fang J J Biol Chem 2015[Jun]; 290 (24 ): 15327-36 PMID25925952 show ga Intestinal epithelial cells (IECs) have critical roles in maintaining homeostasis of intestinal epithelium. Endoplasmic reticulum (ER) stress is implicated in intestinal epithelium homeostasis and inflammatory bowel disease; however, it remains elusive whether IRE1?, a major sensor of ER stress, is directly involved in these processes. We demonstrate here that genetic ablation of Ire1? in IECs leads to spontaneous colitis in mice. Deletion of IRE1? in IECs results in loss of goblet cells and failure of intestinal epithelial barrier function. IRE1? deficiency induces cell apoptosis through induction of CHOP, the pro-apoptotic protein, and sensitizes cells to lipopolysaccharide, an endotoxin from bacteria. IRE1? deficiency confers upon mice higher susceptibility to chemical-induced colitis. These results suggest that IRE1? functions to maintain the intestinal epithelial homeostasis and plays an important role in defending against inflammation bowel diseases. |Animals [MESH] |Base Sequence [MESH] |Cell Line [MESH] |Colitis/*prevention & control [MESH] |DNA Primers [MESH] |Endoplasmic Reticulum/*metabolism [MESH] |Endoribonucleases/genetics/*physiology [MESH] |Homeostasis [MESH] |Intestinal Mucosa/*metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Polymerase Chain Reaction [MESH] |Protein Serine-Threonine Kinases/genetics/*physiology [MESH]The Endoplasmic Reticulum Stress Sensor IRE1? in Intestinal Epithelial(epmc).pdf DeepDyve Pubget Overpricing