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10.1074/jbc.M115.652156

http://scihub22266oqcxt.onion/10.1074/jbc.M115.652156
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C4463443!4463443!25925951
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suck abstract from ncbi


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pmid25925951      J+Biol+Chem 2015 ; 290 (24): 14979-85
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  • Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab* #MMPMID25925951
  • Oganesyan V; Peng L; Woods RM; Wu H; Dall'Acqua WF
  • J Biol Chem 2015[Jun]; 290 (24): 14979-85 PMID25925951show ga
  • Background: We investigated the molecular basis of human IFN-?2A recognition by sifalimumab.Results: We determined the structure of the complex between the Fab of sifalimumab and IFN-?2A.Conclusion: The interferon-neutralizing properties of sifalimumab result from direct competition for IFN-?2A binding to IFN receptor subunit 1 and not IFN receptor subunit 2.Significance: These data provide the basis for the mechanism of action of sifalimumab.
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