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10.1074/jbc.M115.638361

http://scihub22266oqcxt.onion/10.1074/jbc.M115.638361
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C4463433!4463433!25918169
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suck abstract from ncbi


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pmid25918169      J+Biol+Chem 2015 ; 290 (24): 14852-65
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  • K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells* #MMPMID25918169
  • Costales P; Fuentes-Prior P; Castellano J; Revuelta-Lopez E; Corral-Rodríguez MÁ; Nasarre L; Badimon L; Llorente-Cortes V
  • J Biol Chem 2015[Jun]; 290 (24): 14852-65 PMID25918169show ga
  • Background: LRP1 plays a major role in foam cell formation from human vascular smooth muscle cells (hVSMCs).Results: Antibodies generated against the C-terminal half of cluster II CR9 domain (Gly1127?Cys1140) efficiently prevented hVSMC foam cell formation.Conclusion: CR9 is key for AgLDL binding and internalization.Significance: Our results open new avenues for treating vascular lipid deposition in atherosclerosis.
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