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2014 ; 20
(5
): 374-8
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Renal diffusion-weighted imaging in diabetic nephropathy: correlation with
clinical stages of disease
#MMPMID25010370
Cakmak P
; Ya?c? AB
; Dursun B
; Herek D
; Fenkçi SM
Diagn Interv Radiol
2014[Sep]; 20
(5
): 374-8
PMID25010370
show ga
PURPOSE: We aimed to assess the correlation between renal apparent diffusion
coefficient (ADC) values measured by diffusion-weighted imaging (DWI) and the
clinical stages of diabetic nephropathy. MATERIALS AND METHODS: DWI (b value, 0
and 600 s/mm2) was performed in 78 patients with clinically confirmed diabetic
nephropathy (study group) and 22 volunteers without diabetes mellitus or any
renal disease (control group). The mean ADCs were calculated from multiple
region-of-interest circles positioned in the renal cortex. Diabetic nephropathy
was clinically categorized into five stages based on the values of urinary
albumin excretion and glomerular filtration rate (GFR). RESULTS: Mean renal ADC
values of patients with stage 3 or 4 disease were significantly lower than those
in patients with stage 1 or 2 disease and the control group (P < 0.001). ADC
values of patients with stage 5 disease were significantly lower than those in
patients with stage 4 (P = 0.003), stage 3 (P = 0.020), stages 2 and 1, and the
control group (P < 0.001). Significant correlations were found between mean renal
ADC values and clinical stages of diabetic nephropathy (r=-0.751, P < 0.001),
between mean renal ADC values and estimated GFR values (r=0.642, P < 0.001), and
between mean renal ADC values and urinary albumin excretion (r=-0.419, P <
0.001). CONCLUSION: Renal ADC values show a significant correlation with clinical
stages of diabetic nephropathy. As a relatively simple and noninvasive tool
without contrast media administration, renal quantitative DWI may potentially
play a role in making clinical decisions in the follow-up of diabetic patients.