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10.1111/cas.12489 http://scihub22266oqcxt.onion/10.1111/cas.12489 C4462352!4462352 !25098609     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25098609 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2014 ; 105 (10 ): 1351-9 Nephropedia Template TP {{tp|p=25098609 |t=2014. Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance |pdf=|usr=}}{{25098609 }} gab.com Text Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25098609 #FOAvip Standard fractionated radiotherapy for the treatment of cancer consists of daily irradiation of 2-Gy X-rays, 5 days a week for 5-8 weeks. To understand the characteristics of radioresistant cancer cells and to develop more effective radiotherapy, we established a series of novel, clinically relevant radioresistant (CRR) cells that continue to proliferate with 2-Gy X-ray exposure every 24 h for more than 30 days in vitro. We studied three human and one murine cell line, and their CRR derivatives. Guanine nucleotide-binding protein 1 (GBP1) gene expression was higher in all CRR cells than their corresponding parental cells. GBP1 knockdown by siRNA cancelled radioresistance of CRR cells in vitro and in xenotransplanted tumor tissues in nude mice. The clinical relevance of GBP1 was immunohistochemically assessed in 45 cases of head and neck cancer tissues. Patients with GBP1-positive cancer tended to show poorer response to radiotherapy. We recently reported that low dose long-term fractionated radiation concentrates cancer stem cells (CSCs). Immunofluorescence staining of GBP1 was stronger in CRR cells than in corresponding parental cells. The frequency of Oct4-positive CSCs was higher in CRR cells than in parental cells, however, was not as common as GBP1-positive cells. GBP1-positive cells were radioresistant, but radioresistant cells were not necessarily CSCs. We concluded that GBP1 overexpression is necessary for the radioresistant phenotype in CRR cells, and that targeting GBP1-positive cancer cells is a more efficient method in conquering cancer than targeting CSCs. Twit Text FOAVip Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25098609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25098609 #FOAvip English Wikipedia <ref>{{Cite pmid|25098609 }}</ref> Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance #MMPMID25098609 Fukumoto M ; Amanuma T ; Kuwahara Y ; Shimura T ; Suzuki M ; Mori S ; Kumamoto H ; Saito Y ; Ohkubo Y ; Duan Z ; Sano K ; Oguchi T ; Kainuma K ; Usami S ; Kinoshita K ; Lee I ; Fukumoto M Cancer Sci 2014[Oct]; 105 (10 ): 1351-9 PMID25098609 show ga Standard fractionated radiotherapy for the treatment of cancer consists of daily irradiation of 2-Gy X-rays, 5 days a week for 5-8 weeks. To understand the characteristics of radioresistant cancer cells and to develop more effective radiotherapy, we established a series of novel, clinically relevant radioresistant (CRR) cells that continue to proliferate with 2-Gy X-ray exposure every 24 h for more than 30 days in vitro. We studied three human and one murine cell line, and their CRR derivatives. Guanine nucleotide-binding protein 1 (GBP1) gene expression was higher in all CRR cells than their corresponding parental cells. GBP1 knockdown by siRNA cancelled radioresistance of CRR cells in vitro and in xenotransplanted tumor tissues in nude mice. The clinical relevance of GBP1 was immunohistochemically assessed in 45 cases of head and neck cancer tissues. Patients with GBP1-positive cancer tended to show poorer response to radiotherapy. We recently reported that low dose long-term fractionated radiation concentrates cancer stem cells (CSCs). Immunofluorescence staining of GBP1 was stronger in CRR cells than in corresponding parental cells. The frequency of Oct4-positive CSCs was higher in CRR cells than in parental cells, however, was not as common as GBP1-positive cells. GBP1-positive cells were radioresistant, but radioresistant cells were not necessarily CSCs. We concluded that GBP1 overexpression is necessary for the radioresistant phenotype in CRR cells, and that targeting GBP1-positive cancer cells is a more efficient method in conquering cancer than targeting CSCs. |*Radiation Tolerance [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |GTP-Binding Proteins/analysis/*physiology [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Neoplasms/pathology/*radiotherapy [MESH] |Neoplastic Stem Cells/*radiation effects [MESH] |Octamer Transcription Factor-3/analysis [MESH]Guanine nucleotide-binding protein 1 is one of the key molecules contr(epmc).pdf DeepDyve Pubget Overpricing