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10.1111/cas.12499 http://scihub22266oqcxt.onion/10.1111/cas.12499 C4462345!4462345!25130698     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2014 ; 105 (10): 1288-98 Nephropedia Template TP {{tp|p=25130698|t=2014. miR-639 regulates transforming growth factor beta-induced epithelial?mesenchymal transition in human tongue cancer cells by targeting FOXC1 |pdf=|usr=}}{{25130698}} gab.com Text miR-639 regulates transforming growth factor beta-induced epithelial mesenchymal transition in human tongue cancer cells by targeting FOXC1 JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25130698 #FOAvip Epithelial-to-mesenchymal transition (EMT) is implicated in embryonic development and various pathological events. Transforming growth factor beta (TGF?) has been reported to induce EMT in tumor cells, which is a critical step in the process of metastasis leading to cancer spreading and treatment failure. However, the involvement of microRNA during the EMT process in tongue squamous cell carcinoma (TSCC) remains to be determined. To address this question, TSCC cell lines SCC9 and CAL27 were treated with human recombinant TGF?1 for 48 h. miRNA microarray illustrated that miR-639 was significantly downregulated in TGF?-treated SCC9 cells. Ectopic expression of miR-639 with miRNA mimics effectively blocked TGF?-induced EMT in SCC9 and CAL27 cells, but inhibition of miR-639 in SCC9 and CAL27 cells with antisense oligonucleotides induced EMT. Computational microRNA target predictions detected a conserved sequence matching to the seed region of miR-639 in the 3?-UTR of FOXC1 mRNA. Luciferase reporter assays revealed that miR-639 targets FOXC1. Ectopic expression of FOXC1 induces EMT in TSCC cells. Silencing FOXC1 expression blocked TGF?-induced EMT in SCC9 cells. Clinically, reduced miR-639 expression was associated with metastasis in TSCC and poor patient survival. The data from the present study suggest that reduced expression of miR-639 underscores the mechanism of TGF?-induced EMT in TSCC by targeting FOXC1 and may serve as therapeutic targets in the process of metastasis. Twit Text FOAVip miR-639 regulates transforming growth factor beta-induced epithelial mesenchymal transition in human tongue cancer cells by targeting FOXC1 ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25130698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25130698 #FOAvip English Wikipedia <ref>{{Cite pmid|25130698}}</ref> miR-639 regulates transforming growth factor beta-induced epithelial?mesenchymal transition in human tongue cancer cells by targeting FOXC1 #MMPMID25130698 Lin Z; Sun L; Chen W; Liu B; Wang Y; Fan S; Li Y; Li J Cancer Sci 2014[Oct]; 105 (10): 1288-98 PMID25130698show ga Epithelial-to-mesenchymal transition (EMT) is implicated in embryonic development and various pathological events. Transforming growth factor beta (TGF?) has been reported to induce EMT in tumor cells, which is a critical step in the process of metastasis leading to cancer spreading and treatment failure. However, the involvement of microRNA during the EMT process in tongue squamous cell carcinoma (TSCC) remains to be determined. To address this question, TSCC cell lines SCC9 and CAL27 were treated with human recombinant TGF?1 for 48 h. miRNA microarray illustrated that miR-639 was significantly downregulated in TGF?-treated SCC9 cells. Ectopic expression of miR-639 with miRNA mimics effectively blocked TGF?-induced EMT in SCC9 and CAL27 cells, but inhibition of miR-639 in SCC9 and CAL27 cells with antisense oligonucleotides induced EMT. Computational microRNA target predictions detected a conserved sequence matching to the seed region of miR-639 in the 3?-UTR of FOXC1 mRNA. Luciferase reporter assays revealed that miR-639 targets FOXC1. Ectopic expression of FOXC1 induces EMT in TSCC cells. Silencing FOXC1 expression blocked TGF?-induced EMT in SCC9 cells. Clinically, reduced miR-639 expression was associated with metastasis in TSCC and poor patient survival. The data from the present study suggest that reduced expression of miR-639 underscores the mechanism of TGF?-induced EMT in TSCC by targeting FOXC1 and may serve as therapeutic targets in the process of metastasis. ämiR-639 regulates transforming growth factor beta-induced epithelial?m(epmc).pdf DeepDyve Pubget Overpricing