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2014 ; 49
(3
): 210-6
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Profile of the patients who present to immunology outpatient clinics because of
frequent infections
#MMPMID26078665
Ald?rmaz S
; Yücel E
; K?yk?m A
; Çoku?ra? H
; Akçakaya N
; Camc?o?lu Y
Turk Pediatri Ars
2014[Sep]; 49
(3
): 210-6
PMID26078665
show ga
AIM: We aimed to determine the rate of primary immune deficiency (PID) among
children presenting to our immunology outpatient clinic with a history of
frequent infections and with warning signs of primary immune deficiency. MATERIAL
AND METHODS: The files of 232 children aged between 1 and 18 years with warning
signs of primary immune deficiency who were referred to our pediatric immunology
outpatient clinic with a complaint of frequent infections were selected and
evaluated retrospectively. RESULTS: Thirty-six percent of the subjects were
female (n=84) and 64% were male (n=148). PID was found in 72.4% (n=164). The most
common diagnosis was selective IgA deficiency (26.3%, n=61). The most common
diseases other than primary immune deficiency included reactive airway disease
and/or atopy (34.4%, n=22), adenoid vegetation (12.3%, n=8), chronic disease
(6.3%, n=4) and periodic fever, aphtous stomatitis and adenopathy (4.6%, n=3).
The majortiy of the subjects (90.5%, n=210) presented with a complaint of
recurrent upper respiratory tract infection. PID was found in all subjects who
had bronchiectasis. The rates of the diagnoses of variable immune deficiency and
Bruton agammaglubulinemia (XLA) were found to be significantly higher in the
subjects who had lower respiratory tract infection, who were hospitalized because
of infection and who had a history of severe infection compared to the subjects
who did not have these properties (p<0.05 and p<0.01, respectively). Growth and
developmental failure was found with a significantly higher rate in the patients
who had a diagnosis of severe combined immune deficiency or hyper IgM compared to
the other subjects (p<0.01). No difference was found in the rates of PID between
the age groups, but the diagnosis of XLA increased as the age of presentation
increased and this was considered an indicator which showed that patients with
XLA were being diagnosed in a late period. CONCLUSIONS: It was found that the
rate of diagnosis was considerably high (72.4%), when the subjects who had
frequent infections were selected by the warning signs of PID.