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10.1038/srep11219 http://scihub22266oqcxt.onion/10.1038/srep11219 C4462147!4462147 !26061387     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26061387 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2015 ; 5 (?): 11219 Nephropedia Template TP {{tp|p=26061387 |t=2015. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy |pdf=|usr=}}{{26061387 }} gab.com Text Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26061387 #FOAvip Danhong Injection (DHI), a Chinese medicine for treatment of patients with coronary heart disease, inhibits primary abdominal aortic aneurysms in apoE deficient (apoE(-/-)) mice. Formation of microaneurysms plays an important role in the development of diabetic retinopathy and nephropathy. It remains unknown if DHI can reduce these diabetic complications. In this study, diabetic db/db mice in two groups were injected with saline and DHI, respectively, for 14 weeks. Blood and tissue samples were collected to determine serum glucose, lipids and tissue structure. DHI reduced diabetes-induced body weight gain, serum cholesterol and glucose levels. In retinas, DHI blocked the shrink of whole retina and retinal sub-layers by inhibiting expression of caspase 3, matrix metalloproteinase 2 (MMP-2) and MMP-9, accumulation of carbohydrate macromolecules and formation of acellular capillaries. DHI improved renal functions by inhibiting mesangial matrix expansion, expression of vascular endothelial growth factor A, fibronectin and advanced glycation end products in kidneys. Mechanistically, DHI induced expression of glucokinase, AMPK?/phosphorylated AMPK?, insulin receptor substrate 1, fibroblast growth factor 21 and peroxisome proliferator-activated ?. Expression of genes responsible for energy expenditure was also activated by DHI. Therefore, DHI inhibits diabetic retinopathy and nephropathy by ameliorating glucose metabolism and demonstrates a potential application in clinics. Twit Text FOAVip Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26061387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26061387 #FOAvip English Wikipedia <ref>{{Cite pmid|26061387 }}</ref> Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy #MMPMID26061387 Liu M ; Pan Q ; Chen Y ; Yang X ; Zhao B ; Jia L ; Zhu Y ; Zhang B ; Gao X ; Li X ; Han J ; Duan Y Sci Rep 2015[Jun]; 5 (?): 11219 PMID26061387 show ga Danhong Injection (DHI), a Chinese medicine for treatment of patients with coronary heart disease, inhibits primary abdominal aortic aneurysms in apoE deficient (apoE(-/-)) mice. Formation of microaneurysms plays an important role in the development of diabetic retinopathy and nephropathy. It remains unknown if DHI can reduce these diabetic complications. In this study, diabetic db/db mice in two groups were injected with saline and DHI, respectively, for 14 weeks. Blood and tissue samples were collected to determine serum glucose, lipids and tissue structure. DHI reduced diabetes-induced body weight gain, serum cholesterol and glucose levels. In retinas, DHI blocked the shrink of whole retina and retinal sub-layers by inhibiting expression of caspase 3, matrix metalloproteinase 2 (MMP-2) and MMP-9, accumulation of carbohydrate macromolecules and formation of acellular capillaries. DHI improved renal functions by inhibiting mesangial matrix expansion, expression of vascular endothelial growth factor A, fibronectin and advanced glycation end products in kidneys. Mechanistically, DHI induced expression of glucokinase, AMPK?/phosphorylated AMPK?, insulin receptor substrate 1, fibroblast growth factor 21 and peroxisome proliferator-activated ?. Expression of genes responsible for energy expenditure was also activated by DHI. Therefore, DHI inhibits diabetic retinopathy and nephropathy by ameliorating glucose metabolism and demonstrates a potential application in clinics. |Animals [MESH] |Biomarkers/metabolism/urine [MESH] |Caspase 3/metabolism [MESH] |Caspase Inhibitors/administration & dosage/pharmacology [MESH] |Diabetic Nephropathies/*drug therapy/genetics/pathology/prevention & control [MESH] |Diabetic Retinopathy/*drug therapy/genetics/pathology/prevention & control [MESH] |Disease Models, Animal [MESH] |Drugs, Chinese Herbal/*administration & dosage/pharmacology [MESH] |Energy Metabolism/drug effects [MESH] |Glycation End Products, Advanced/metabolism [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Matrix Metalloproteinase Inhibitors/administration & dosage/pharmacology [MESH] |Mice [MESH]Administration of Danhong Injection to diabetic db/db mice inhibits th(epmc).pdf DeepDyve Pubget Overpricing