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10.1038/srep11239 http://scihub22266oqcxt.onion/10.1038/srep11239 C4462032!4462032!26058812     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26058812|t=2015. Novel Function of Rev-erb? in Promoting Brown Adipogenesis |pdf=|usr=}}{{26058812}} gab.com Text Novel Function of Rev-erb in Promoting Brown Adipogenesis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26058812 #FOAvip Brown adipose tissue is a major thermogenic organ that plays a key role in maintenance of body temperature and whole-body energy homeostasis. Rev-erb?, a ligand-dependent nuclear receptor and transcription repressor of the molecular clock, has been implicated in the regulation of adipogenesis. However, whether Rev-erb? participates in brown fat formation is not known. Here we show that Rev-erb? is a key regulator of brown adipose tissue development by promoting brown adipogenesis. Genetic ablation of Rev-erb? in mice severely impairs embryonic and neonatal brown fat formation accompanied by loss of brown identity. This defect is due to a cell-autonomous function of Rev-erb? in brown adipocyte lineage commitment and terminal differentiation, as demonstrated by genetic loss- and gain-of-function studies in mesenchymal precursors and brown preadipocytes. Moreover, pharmacological activation of Rev-erb? activity promotes, whereas its inhibition suppresses brown adipocyte differentiation. Mechanistic investigations reveal that Rev-erb? represses key components of the TGF-? cascade, an inhibitory pathway of brown fat development. Collectively, our findings delineate a novel role of Rev-erb? in driving brown adipocyte development, and provide experimental evidence that pharmacological interventions of Rev-erb? may offer new avenues for the treatment of obesity and related metabolic disorders. Twit Text FOAVip Novel Function of Rev-erb in Promoting Brown Adipogenesis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26058812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26058812 #FOAvip English Wikipedia <ref>{{Cite pmid|26058812}}</ref> Novel Function of Rev-erb? in Promoting Brown Adipogenesis #MMPMID26058812 Nam D; Chatterjee S; Yin H; Liu R; Lee J; Yechoor VK; Ma K Sci Rep 2015[]; 5 (ä): ä PMID26058812show ga Brown adipose tissue is a major thermogenic organ that plays a key role in maintenance of body temperature and whole-body energy homeostasis. Rev-erb?, a ligand-dependent nuclear receptor and transcription repressor of the molecular clock, has been implicated in the regulation of adipogenesis. However, whether Rev-erb? participates in brown fat formation is not known. Here we show that Rev-erb? is a key regulator of brown adipose tissue development by promoting brown adipogenesis. Genetic ablation of Rev-erb? in mice severely impairs embryonic and neonatal brown fat formation accompanied by loss of brown identity. This defect is due to a cell-autonomous function of Rev-erb? in brown adipocyte lineage commitment and terminal differentiation, as demonstrated by genetic loss- and gain-of-function studies in mesenchymal precursors and brown preadipocytes. Moreover, pharmacological activation of Rev-erb? activity promotes, whereas its inhibition suppresses brown adipocyte differentiation. Mechanistic investigations reveal that Rev-erb? represses key components of the TGF-? cascade, an inhibitory pathway of brown fat development. Collectively, our findings delineate a novel role of Rev-erb? in driving brown adipocyte development, and provide experimental evidence that pharmacological interventions of Rev-erb? may offer new avenues for the treatment of obesity and related metabolic disorders. äNovel Function of Rev-erb? in Promoting Brown Adipogenesis (epmc).pdf DeepDyve Pubget Overpricing