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10.1038/mtna.2014.48 http://scihub22266oqcxt.onion/10.1038/mtna.2014.48 C4461992!4461992!25405466     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther+Nucleic+Acids 2014 ; 3 (11): e197- Nephropedia Template TP {{tp|p=25405466|t=2014. A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus |pdf=|usr=}}{{25405466}} gab.com Text A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus JO: Mol Ther Nucleic Acids http://www.kidney.de/pget.php?&tw=1&pmid=25405466 #FOAvip This review discusses recent developments in the use of non-coding RNAs (ncRNAs) for the regulation of therapeutically relevant genes, with special focus on applications for the treatment of cardiovascular diseases. The interest in using ncRNAs as therapeutics has steadily increased since the discovery of RNA interference. During the last decade it has become evident that these RNAs, delivered either as oligos or expressed as small hairpin RNAs (shRNAs) from vectors, can either upregulate (transcriptional gene activation, TGA) or downregulate (transcriptional gene silencing, TGS) gene expression, typically inducing epigenetic changes in their target sites in the chromatin. Also, the important role of naturally occurring long non-coding RNAs (lncRNAs) has been recently discovered and will likely provide new insights into cardiovascular pathology and provide new treatment strategies based on the manipulation of their expression. In this review, we discuss the possibility of using ncRNAs for activating or silencing therapeutically relevant genes, such as VEGF-A, for the treatment of cardiovascular disease. Twit Text FOAVip A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus ????Mol Ther Nucleic Acids http://www.kidney.de/pget.php?&tw=1&pmid=25405466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25405466 #FOAvip English Wikipedia <ref>{{Cite pmid|25405466}}</ref> A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus #MMPMID25405466 Husso T; Ylä-Herttuala S; Turunen MP Mol Ther Nucleic Acids 2014[Nov]; 3 (11): e197- PMID25405466show ga This review discusses recent developments in the use of non-coding RNAs (ncRNAs) for the regulation of therapeutically relevant genes, with special focus on applications for the treatment of cardiovascular diseases. The interest in using ncRNAs as therapeutics has steadily increased since the discovery of RNA interference. During the last decade it has become evident that these RNAs, delivered either as oligos or expressed as small hairpin RNAs (shRNAs) from vectors, can either upregulate (transcriptional gene activation, TGA) or downregulate (transcriptional gene silencing, TGS) gene expression, typically inducing epigenetic changes in their target sites in the chromatin. Also, the important role of naturally occurring long non-coding RNAs (lncRNAs) has been recently discovered and will likely provide new insights into cardiovascular pathology and provide new treatment strategies based on the manipulation of their expression. In this review, we discuss the possibility of using ncRNAs for activating or silencing therapeutically relevant genes, such as VEGF-A, for the treatment of cardiovascular disease. äA New Gene Therapy Approach for Cardiovascular Disease by Non-coding R(epmc).pdf DeepDyve Pubget Overpricing