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10.1111/j.1600-6143.2012.04265.x http://scihub22266oqcxt.onion/10.1111/j.1600-6143.2012.04265.x C4461878!4461878 !22994609     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22994609 &cmd=llinks): Failed to open stream: HTTP request failed! 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Successful transplantation of reduced-sized rat alcoholic fatty livers made possible by mobilization of host stem cells |pdf=|usr=}}{{22994609 }} gab.com Text Successful transplantation of reduced-sized rat alcoholic fatty livers made possible by mobilization of host stem cells JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=22994609 #FOAvip Livers from Lewis rats fed with 7% alcohol for 5 weeks were used for transplantation. Reduced sized (50%) livers or whole livers were transplanted into normal DA recipients, which, in this strain combination, survive indefinitely when the donor has not been fed alcohol. However, none of the rats survived a whole fatty liver transplant while six of seven recipients of reduced sized alcoholic liver grafts survived long term. SDF-1 and HGF were significantly increased in reduced size liver grafts compared to whole liver grafts. Lineage-negative Thy-1+CXCR4+CD133+ stem cells were significantly increased in the peripheral blood and in allografts after reduced size fatty liver transplantation. In contrast, there were meager increases in cells reactive with anti Thy-1, CXCR4 and CD133 in peripheral blood and allografts in whole alcoholic liver recipients. The provision of plerixafor, a stem cell mobilizer, salvaged 5 of 10 whole fatty liver grafts. Conversely, blocking SDF-1 activity with neutralizing antibodies diminished stem cell recruitment and four of five reduced sized fatty liver recipients died. Thus chemokine insufficiency was associated with transplant failure of whole grafts, which was overcome by the increased regenerative requirements promoted by the small grafts and mediated by SDF-1 resulting in stem cell influx. Twit Text FOAVip Successful transplantation of reduced-sized rat alcoholic fatty livers made possible by mobilization of host stem cells ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=22994609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22994609 #FOAvip English Wikipedia <ref>{{Cite pmid|22994609 }}</ref> Successful transplantation of reduced-sized rat alcoholic fatty livers made possible by mobilization of host stem cells #MMPMID22994609 Hisada M ; Ota Y ; Zhang X ; Cameron AM ; Gao B ; Montgomery RA ; Williams GM ; Sun Z Am J Transplant 2012[Dec]; 12 (12 ): 3246-56 PMID22994609 show ga Livers from Lewis rats fed with 7% alcohol for 5 weeks were used for transplantation. Reduced sized (50%) livers or whole livers were transplanted into normal DA recipients, which, in this strain combination, survive indefinitely when the donor has not been fed alcohol. However, none of the rats survived a whole fatty liver transplant while six of seven recipients of reduced sized alcoholic liver grafts survived long term. SDF-1 and HGF were significantly increased in reduced size liver grafts compared to whole liver grafts. Lineage-negative Thy-1+CXCR4+CD133+ stem cells were significantly increased in the peripheral blood and in allografts after reduced size fatty liver transplantation. In contrast, there were meager increases in cells reactive with anti Thy-1, CXCR4 and CD133 in peripheral blood and allografts in whole alcoholic liver recipients. The provision of plerixafor, a stem cell mobilizer, salvaged 5 of 10 whole fatty liver grafts. Conversely, blocking SDF-1 activity with neutralizing antibodies diminished stem cell recruitment and four of five reduced sized fatty liver recipients died. Thus chemokine insufficiency was associated with transplant failure of whole grafts, which was overcome by the increased regenerative requirements promoted by the small grafts and mediated by SDF-1 resulting in stem cell influx. |*Hematopoietic Stem Cell Mobilization [MESH] |*Liver Transplantation [MESH] |Animals [MESH] |Anti-HIV Agents/pharmacology [MESH] |Benzylamines [MESH] |Blotting, Western [MESH] |Chemokine CXCL12/genetics/metabolism [MESH] |Cyclams [MESH] |Fatty Liver, Alcoholic/immunology/mortality/*therapy [MESH] |Fluorescent Antibody Technique [MESH] |Graft Rejection/immunology/prevention & control [MESH] |Heterocyclic Compounds/pharmacology [MESH] |Immunoenzyme Techniques [MESH] |Liver/cytology/drug effects/*immunology [MESH] |RNA, Messenger/genetics [MESH] |Rats [MESH] |Rats, Inbred Lew [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Stem Cells/*cytology/immunology [MESH] |Survival Rate [MESH]Successful transplantation of reduced-sized rat alcoholic fatty livers(epmc).pdf DeepDyve Pubget Overpricing