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10.3389/fphys.2015.00174 http://scihub22266oqcxt.onion/10.3389/fphys.2015.00174 C4461830!4461830!26113821     free     free     free       Front+Physiol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26113821|t=2015. A new paradigm for muscle contraction |pdf=|usr=}}{{26113821}} gab.com Text A new paradigm for muscle contraction JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26113821 #FOAvip For the past 60 years, muscle contraction had been thought to be governed exclusively by the contractile filaments, actin, and myosin. This thinking explained most observations for concentric and isometric, but not for eccentric muscle contractions. Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin. Titin was found to bind calcium upon activation, thereby increasing its structural stability, and thus its stiffness and force. Furthermore, there is increasing evidence that the proximal part of titin binds to actin in an activation- and force-dependent manner, thereby shortening its free length, thus increasing its stiffness and force. Therefore, we propose that muscle contraction involves three filaments, actin, myosin and titin, and that titin regulates force by binding calcium and by shortening its spring length by binding to actin. Twit Text FOAVip A new paradigm for muscle contraction ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26113821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26113821 #FOAvip English Wikipedia <ref>{{Cite pmid|26113821}}</ref> A new paradigm for muscle contraction #MMPMID26113821 Herzog W; Powers K; Johnston K; Duvall M Front Physiol 2015[]; 6 (ä): ä PMID26113821show ga For the past 60 years, muscle contraction had been thought to be governed exclusively by the contractile filaments, actin, and myosin. This thinking explained most observations for concentric and isometric, but not for eccentric muscle contractions. Just over a decade ago, we discovered that eccentric contractions were associated with a force that could not be assigned to actin and myosin, but was at least in part associated with the filamentous protein titin. Titin was found to bind calcium upon activation, thereby increasing its structural stability, and thus its stiffness and force. Furthermore, there is increasing evidence that the proximal part of titin binds to actin in an activation- and force-dependent manner, thereby shortening its free length, thus increasing its stiffness and force. Therefore, we propose that muscle contraction involves three filaments, actin, myosin and titin, and that titin regulates force by binding calcium and by shortening its spring length by binding to actin. äA new paradigm for muscle contraction (epmc).pdf DeepDyve Pubget Overpricing