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2015 ; 2015
(ä): 587893
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Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series
of Patients from Argentina
#MMPMID26106414
Bruno OD
; Juárez-Allen L
; Christiansen SB
; Manavela M
; Danilowicz K
; Vigovich C
; Gómez RM
Int J Endocrinol
2015[]; 2015
(ä): 587893
PMID26106414
show ga
We evaluated results of temozolomide (TMZ) therapy in six patients, aged 34-78
years, presenting aggressive pituitary tumors. In all the patients tested
O(6)-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical
specimens was absent. Patients received temozolomide 140-320?mg/day for 5 days
monthly for at least 3 months. In two patients minimum time for evaluation could
not be reached because of death in a 76-year-old man with a malignant
prolactinoma and of severe neutro-thrombopenia in a 47-year-old woman with
nonfunctioning pituitary adenoma. In two patients (a 34-year-old acromegalic
woman and a 39-year-old woman with Nelson's syndrome) no response was observed
after 4 and 6 months, respectively, and the treatment was stopped. Conversely,
two 52- and 42-year-old women with Cushing's disease had long-term total clinical
and radiological remissions which persisted after stopping temozolomide. We
conclude that TMZ therapy may be of variable efficacy depending on-until
now-incompletely understood factors. Cooperative work on a greater number of
cases of aggressive pituitary tumors should be crucial to establish the
indications, doses, and duration of temozolomide administration.