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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Diabetes+Res 2015 ; 2015 (ä): ä Nephropedia Template TP
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Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study #MMPMID26106626
Tuomainen TP; Virtanen JK; Voutilainen S; Nurmi T; Mursu J; de Mello VDF; Schwab U; Hakumäki M; Pulkki K; Uusitupa M
J Diabetes Res 2015[]; 2015 (ä): ä PMID26106626show ga
Epidemiological evidence suggests a role for vitamin D in type 2 diabetes prevention. We investigated the effects of vitamin D3 supplementation on glucose metabolism and inflammation in subjects with prediabetes. A 5-month randomized, double-blind, placebo-controlled intervention with three arms (placebo, 40??g/d, or 80??g/d vitamin D3) was carried out among sixty-eight overweight (BMI 25?35) and aging (?60 years) subjects from Finland, with serum 25-hydroxyvitamin D3 [25(OH)D3] < 75?nmol/L and either impaired fasting glucose or impaired glucose tolerance. Analyses included 66 subjects who completed the trial. Glucose metabolism was evaluated by fasting and 2-hour oral glucose tolerance test-derived indices and glycated hemoglobin. Inflammation was evaluated by high-sensitive C-reactive protein and five cytokines. Although a dose-dependent increase in serum 25(OH)D3 over the supplementation period was observed (P trend < 0.001), there were no other statistically significant differences in changes in the 13 glucose homeostasis indicators between the study groups other than increase in the 120?min glucose concentration (P trend = 0.021) and a decreasing trend both in 30?min plasma insulin (P trend = 0.030) and glycated hemoglobin (P trend = 0.024) concentrations. A borderline statistically significant decreasing trend in interleukin-1 receptor antagonist concentration was observed (P = 0.070). Vitamin D3 supplementation does not improve glucose metabolism in ageing subjects with prediabetes but may have modest anti-inflammatory effects.