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10.1155/2015/672653

http://scihub22266oqcxt.onion/10.1155/2015/672653
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suck abstract from ncbi


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pmid26106626
      J+Diabetes+Res 2015 ; 2015 (ä): 672653
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  • Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized Placebo-Controlled Supplementation Study #MMPMID26106626
  • Tuomainen TP ; Virtanen JK ; Voutilainen S ; Nurmi T ; Mursu J ; de Mello VD ; Schwab U ; Hakumäki M ; Pulkki K ; Uusitupa M
  • J Diabetes Res 2015[]; 2015 (ä): 672653 PMID26106626 show ga
  • Epidemiological evidence suggests a role for vitamin D in type 2 diabetes prevention. We investigated the effects of vitamin D3 supplementation on glucose metabolism and inflammation in subjects with prediabetes. A 5-month randomized, double-blind, placebo-controlled intervention with three arms (placebo, 40 ?g/d, or 80 ?g/d vitamin D3) was carried out among sixty-eight overweight (BMI 25-35) and aging (?60 years) subjects from Finland, with serum 25-hydroxyvitamin D3 [25(OH)D3] < 75 nmol/L and either impaired fasting glucose or impaired glucose tolerance. Analyses included 66 subjects who completed the trial. Glucose metabolism was evaluated by fasting and 2-hour oral glucose tolerance test-derived indices and glycated hemoglobin. Inflammation was evaluated by high-sensitive C-reactive protein and five cytokines. Although a dose-dependent increase in serum 25(OH)D3 over the supplementation period was observed (P trend < 0.001), there were no other statistically significant differences in changes in the 13 glucose homeostasis indicators between the study groups other than increase in the 120 min glucose concentration (P trend = 0.021) and a decreasing trend both in 30 min plasma insulin (P trend = 0.030) and glycated hemoglobin (P trend = 0.024) concentrations. A borderline statistically significant decreasing trend in interleukin-1 receptor antagonist concentration was observed (P = 0.070). Vitamin D3 supplementation does not improve glucose metabolism in ageing subjects with prediabetes but may have modest anti-inflammatory effects.
  • |Aged [MESH]
  • |Blood Glucose/*metabolism [MESH]
  • |C-Reactive Protein/*metabolism [MESH]
  • |Calcifediol/*blood [MESH]
  • |Cholecalciferol/*therapeutic use [MESH]
  • |Cytokines/*metabolism [MESH]
  • |Dietary Supplements [MESH]
  • |Double-Blind Method [MESH]
  • |Female [MESH]
  • |Glucose Tolerance Test [MESH]
  • |Humans [MESH]
  • |Interleukin 1 Receptor Antagonist Protein/metabolism [MESH]
  • |Interleukin-1beta/metabolism [MESH]
  • |Interleukin-6/metabolism [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Overweight/complications/*metabolism [MESH]
  • |Prediabetic State/complications/*drug therapy/metabolism [MESH]
  • |Receptors, Tumor Necrosis Factor, Type II/metabolism [MESH]
  • |Treatment Outcome [MESH]


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