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2015 ; 2015
(ä): 672653
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Glucose Metabolism Effects of Vitamin D in Prediabetes: The VitDmet Randomized
Placebo-Controlled Supplementation Study
#MMPMID26106626
Tuomainen TP
; Virtanen JK
; Voutilainen S
; Nurmi T
; Mursu J
; de Mello VD
; Schwab U
; Hakumäki M
; Pulkki K
; Uusitupa M
J Diabetes Res
2015[]; 2015
(ä): 672653
PMID26106626
show ga
Epidemiological evidence suggests a role for vitamin D in type 2 diabetes
prevention. We investigated the effects of vitamin D3 supplementation on glucose
metabolism and inflammation in subjects with prediabetes. A 5-month randomized,
double-blind, placebo-controlled intervention with three arms (placebo, 40 ?g/d,
or 80 ?g/d vitamin D3) was carried out among sixty-eight overweight (BMI 25-35)
and aging (?60 years) subjects from Finland, with serum 25-hydroxyvitamin D3
[25(OH)D3] < 75 nmol/L and either impaired fasting glucose or impaired glucose
tolerance. Analyses included 66 subjects who completed the trial. Glucose
metabolism was evaluated by fasting and 2-hour oral glucose tolerance
test-derived indices and glycated hemoglobin. Inflammation was evaluated by
high-sensitive C-reactive protein and five cytokines. Although a dose-dependent
increase in serum 25(OH)D3 over the supplementation period was observed (P trend
< 0.001), there were no other statistically significant differences in changes in
the 13 glucose homeostasis indicators between the study groups other than
increase in the 120 min glucose concentration (P trend = 0.021) and a decreasing
trend both in 30 min plasma insulin (P trend = 0.030) and glycated hemoglobin (P
trend = 0.024) concentrations. A borderline statistically significant decreasing
trend in interleukin-1 receptor antagonist concentration was observed (P =
0.070). Vitamin D3 supplementation does not improve glucose metabolism in ageing
subjects with prediabetes but may have modest anti-inflammatory effects.