Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for
Helicobacter pylori Infection: A Systematic Review and Meta-Analysis
#MMPMID26106411
Liu X
; Wang H
; Lv Z
; Wang Y
; Wang B
; Xie Y
; Zhou X
; Lv N
Gastroenterol Res Pract
2015[]; 2015
(?): 415648
PMID26106411
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Background. To conduct a systematic review and meta-analysis of clinical trials
for eradication of Helicobacter pylori (H. pylori) that included a treatment arm
with a proton pump inhibitor, rifabutin, and amoxicillin. Materials and Methods.
We selected clinical trials that examined the efficacy of H. pylori eradication
therapies and included a study arm using the test regimen from major medical
literature databases and abstracts from major gastroenterology meetings. We also
did subgroup and sensitivity analyses. Results. Twenty-one studies were included
in systematic review. The total eradication rates of the test regimen were 70.4%
by intent-to-treat (ITT) and 72.0% by per-protocol (PP) analyses. The pooled odds
ratio (OR) was 0.55 using fixed effects model (P = 0.283) for the test regimen
versus other triple regimens. The total eradication rates were 68.4% for the test
regimen and 81.9% in the control group by ITT, while the OR was 1.08 using random
effects model (P = 0.019). The pooled eradication rate was 66.4% for the test
regimen and 67.4% for the control group by ITT. The total adverse effects
incidence were 25.1% for the test regimen. Conclusions. The test regimen for H.
pylori rescue therapy may be not superior to control regimens in efficacy.
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