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2015 ; 2015
(ä): 670121
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Endoscopic Raman Spectroscopy for Molecular Fingerprinting of Gastric Cancer:
Principle to Implementation
#MMPMID26106612
Kim HH
Biomed Res Int
2015[]; 2015
(ä): 670121
PMID26106612
show ga
Currently, positive endoscopic biopsy is the standard criterion for gastric
cancer diagnosis but is invasive, often inconsistent, and delayed although early
detection and early treatment is the most important policy. Raman spectroscopy is
a spectroscopic technique based on inelastic scattering of monochromatic light.
Raman spectrum represents molecular composition of the interrogated volume
providing a direct molecular fingerprint. Several investigations revealed that
Raman spectroscopy can differentiate normal, dysplastic, and adenocarcinoma
gastric tissue with high sensitivity and specificity. Moreover, this technique
can indentify malignant ulcer and showed the capability to analyze the
carcinogenesis process. Automated on-line Raman spectral diagnostic system raised
possibility to use Raman spectroscopy in clinical field. Raman spectroscopy can
be applied in many fields such as guiding a target biopsy, optical biopsy in
bleeding prone situation, and delineating the margin of the lesion. With wide
field technology, Raman spectroscopy is expected to have specific role in our
future clinical field.