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10.2119/molmed.2014.00211 http://scihub22266oqcxt.onion/10.2119/molmed.2014.00211 C4461580!4461580!25587857     free     free     free       Mol+Med 2015 ; 21 (1): 87-97 Nephropedia Template TP {{tp|p=25587857|t=2015. Sirtuin 1: A Target for Kidney Diseases |pdf=|usr=}}{{25587857}} gab.com Text Sirtuin 1: A Target for Kidney Diseases JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25587857 #FOAvip Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD+-dependent histone deacetylase that is necessary for caloric restriction?related lifespan extension. SIRT1, as an intracellular energy sensor, detects the concentration of intracellular NAD+ and uses this information to adapt cellular energy output to cellular energy requirements. Previous studies on SIRT1 have confirmed its beneficial effects on cellular immunity to oxidative stress, reduction of fibrosis, suppression of inflammation, inhibition of apoptosis, regulation of metabolism, induction of autophagy and regulation of blood pressure. All of the above biological processes are involved in the pathogenesis of kidney diseases. Therefore, the activation of SIRT1 may become a therapeutic target to improve the clinical outcome of kidney diseases. In this review, we give an overview of SIRT1 and its molecular targets as well as SIRT1-modulated biological processes, with a particular focus on the role of SIRT1 in kidney diseases. Twit Text FOAVip Sirtuin 1: A Target for Kidney Diseases ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25587857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25587857 #FOAvip English Wikipedia <ref>{{Cite pmid|25587857}}</ref> Sirtuin 1: A Target for Kidney Diseases #MMPMID25587857 Kong L; Wu H; Zhou W; Luo M; Tan Y; Miao L; Cai L Mol Med 2015[]; 21 (1): 87-97 PMID25587857show ga Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD+-dependent histone deacetylase that is necessary for caloric restriction?related lifespan extension. SIRT1, as an intracellular energy sensor, detects the concentration of intracellular NAD+ and uses this information to adapt cellular energy output to cellular energy requirements. Previous studies on SIRT1 have confirmed its beneficial effects on cellular immunity to oxidative stress, reduction of fibrosis, suppression of inflammation, inhibition of apoptosis, regulation of metabolism, induction of autophagy and regulation of blood pressure. All of the above biological processes are involved in the pathogenesis of kidney diseases. Therefore, the activation of SIRT1 may become a therapeutic target to improve the clinical outcome of kidney diseases. In this review, we give an overview of SIRT1 and its molecular targets as well as SIRT1-modulated biological processes, with a particular focus on the role of SIRT1 in kidney diseases. äSirtuin 1: A Target for Kidney Diseases (epmc).pdf DeepDyve Pubget Overpricing