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10.1111/j.1440-1843.2010.01775.x http://scihub22266oqcxt.onion/10.1111/j.1440-1843.2010.01775.x C4461445!4461445!20546189     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respirology 2010 ; 15 (5): 764-78 Nephropedia Template TP {{tp|p=20546189|t=2010. Current Development and Future Prospects in Chemotherapy of Tuberculosis |pdf=|usr=}}{{20546189}} gab.com Text Current Development and Future Prospects in Chemotherapy of Tuberculosis JO: Respirology http://www.kidney.de/pget.php?&tw=1&pmid=20546189 #FOAvip Although treatment of drug-susceptible tuberculosis (TB) under ideal conditions may be successful in ?95% of cases, cure rates in the field are often significantly lower due to the logistical challenges of administering and properly supervising the intake of combination chemotherapy for 6?9 months. Success rates are far worse for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB cases. There is general agreement that new anti-TB drugs are needed to shorten or otherwise simplify treatment for drug-susceptible and MDR/XDR-TB, including TB associated with HIV infection. For the first time in over 40 years, a nascent pipeline of new anti-TB drug candidates has been assembled. Eleven candidates from 7 classes are currently being evaluated in clinical trials. They include novel chemical entities belonging to entirely new classes of antibacterials, agents approved for use against infections other than TB, and an agent already approved for limited use against TB. In this article, we review the current state of TB treatment and its limitations and provide updates on the status of new drugs in clinical trials. In the conclusion, we briefly highlight ongoing efforts to discover new compounds and recent advances in alternative drug delivery systems. Twit Text FOAVip Current Development and Future Prospects in Chemotherapy of Tuberculosis ????Respirology http://www.kidney.de/pget.php?&tw=1&pmid=20546189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20546189 #FOAvip English Wikipedia <ref>{{Cite pmid|20546189}}</ref> Current Development and Future Prospects in Chemotherapy of Tuberculosis #MMPMID20546189 Nuermberger EL; Spigelman MK; Yew WW Respirology 2010[Jul]; 15 (5): 764-78 PMID20546189show ga Although treatment of drug-susceptible tuberculosis (TB) under ideal conditions may be successful in ?95% of cases, cure rates in the field are often significantly lower due to the logistical challenges of administering and properly supervising the intake of combination chemotherapy for 6?9 months. Success rates are far worse for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB cases. There is general agreement that new anti-TB drugs are needed to shorten or otherwise simplify treatment for drug-susceptible and MDR/XDR-TB, including TB associated with HIV infection. For the first time in over 40 years, a nascent pipeline of new anti-TB drug candidates has been assembled. Eleven candidates from 7 classes are currently being evaluated in clinical trials. They include novel chemical entities belonging to entirely new classes of antibacterials, agents approved for use against infections other than TB, and an agent already approved for limited use against TB. In this article, we review the current state of TB treatment and its limitations and provide updates on the status of new drugs in clinical trials. In the conclusion, we briefly highlight ongoing efforts to discover new compounds and recent advances in alternative drug delivery systems. äCurrent Development and Future Prospects in Chemotherapy of Tuberculos(epmc).pdf DeepDyve Pubget Overpricing