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10.1097/FJC.0000000000000167 http://scihub22266oqcxt.onion/10.1097/FJC.0000000000000167 C4461383!4461383!25264755     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiovasc+Pharmacol 2015 ; 65 (6): 545-8 Nephropedia Template TP {{tp|p=25264755|t=2015. Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad |pdf=|usr=}}{{25264755}} gab.com Text Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad JO: J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25264755 #FOAvip In a number of isolated blood vessel types, hypoxia causes an acute contraction that is dependent on the presence of nitric oxide and activation of soluble guanylyl cyclase. It is more pronounced when the preparations are constricted and is therefore termed hypoxic augmentation of vasoconstriction. This hypoxic response is accompanied by increases in the intracellular level of inosine 5?-triphosphate and in the synthesis of inosine 3?,5?-cyclic monophosphate (cIMP) by soluble guanylyl cyclase. The administration of exogenous cIMP or inosine 5?-triphosphate causes augmented vasoconstriction to hypoxia. Furthermore, the vasoconstriction evoked by hypoxia and cIMP is associated with increased activity of Rho kinase (ROCK), indicating that cIMP may mediate the hypoxic effect by sensitizing the myofilaments to Ca2+ through ROCK. Hypoxia is implicated in exaggerated vasoconstriction in the pathogenesis of coronary artery disease, myocardial infarction, hypertension, and stroke. The newly found role of cIMP may help to identify unique therapeutic targets for certain cardiovascular disorders. Twit Text FOAVip Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad ????J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25264755 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25264755 #FOAvip English Wikipedia <ref>{{Cite pmid|25264755}}</ref> Hypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turns Bad #MMPMID25264755 Gao Y; Chen Z; Leung SWS; Vanhoutte PM J Cardiovasc Pharmacol 2015[Jun]; 65 (6): 545-8 PMID25264755show ga In a number of isolated blood vessel types, hypoxia causes an acute contraction that is dependent on the presence of nitric oxide and activation of soluble guanylyl cyclase. It is more pronounced when the preparations are constricted and is therefore termed hypoxic augmentation of vasoconstriction. This hypoxic response is accompanied by increases in the intracellular level of inosine 5?-triphosphate and in the synthesis of inosine 3?,5?-cyclic monophosphate (cIMP) by soluble guanylyl cyclase. The administration of exogenous cIMP or inosine 5?-triphosphate causes augmented vasoconstriction to hypoxia. Furthermore, the vasoconstriction evoked by hypoxia and cIMP is associated with increased activity of Rho kinase (ROCK), indicating that cIMP may mediate the hypoxic effect by sensitizing the myofilaments to Ca2+ through ROCK. Hypoxia is implicated in exaggerated vasoconstriction in the pathogenesis of coronary artery disease, myocardial infarction, hypertension, and stroke. The newly found role of cIMP may help to identify unique therapeutic targets for certain cardiovascular disorders. äHypoxic Vasospasm Mediated by cIMP: When Soluble Guanylyl Cyclase Turn(epmc).pdf DeepDyve Pubget Overpricing