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10.1002/wrna.1229 http://scihub22266oqcxt.onion/10.1002/wrna.1229 C4461221!4461221!24687772     free     free     free       Wiley+Interdiscip+Rev+RNA 2014 ; 5 (4): 537-48 Nephropedia Template TP {{tp|p=24687772|t=2014. MicroRNAs as therapeutic targets in human cancers |pdf=|usr=}}{{24687772}} gab.com Text MicroRNAs as therapeutic targets in human cancers JO: Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=24687772 #FOAvip MicroRNAs (miRNAs) are evolutionarily conserved, small, regulatory RNAs that negatively regulate gene expression. Extensive research in the last decade has implicated miRNAs as master regulators of cellular processes with essential role in cancer initiation, progression and metastasis, making them promising therapeutic tools for cancer management. In this review, we will briefly review the structure, biogenesis, functions and mechanism of action of these miRNAs, followed by a detailed analysis of the therapeutic potential of these miRNAs. We will focus on the strategies presently used for miRNA therapy; discuss their use and drawbacks, and the challenges and future directions for development of miRNA-based therapy for human cancers. Twit Text FOAVip MicroRNAs as therapeutic targets in human cancers ????Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=24687772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24687772 #FOAvip English Wikipedia <ref>{{Cite pmid|24687772}}</ref> MicroRNAs as therapeutic targets in human cancers #MMPMID24687772 Shah MY; Calin GA Wiley Interdiscip Rev RNA 2014[Jul]; 5 (4): 537-48 PMID24687772show ga MicroRNAs (miRNAs) are evolutionarily conserved, small, regulatory RNAs that negatively regulate gene expression. Extensive research in the last decade has implicated miRNAs as master regulators of cellular processes with essential role in cancer initiation, progression and metastasis, making them promising therapeutic tools for cancer management. In this review, we will briefly review the structure, biogenesis, functions and mechanism of action of these miRNAs, followed by a detailed analysis of the therapeutic potential of these miRNAs. We will focus on the strategies presently used for miRNA therapy; discuss their use and drawbacks, and the challenges and future directions for development of miRNA-based therapy for human cancers. äMicroRNAs as therapeutic targets in human cancers (epmc).pdf DeepDyve Pubget Overpricing