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10.1111/myc.12232 http://scihub22266oqcxt.onion/10.1111/myc.12232 C4461208!4461208!25178879     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25178879&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mycoses 2014 ; 57 (0 3): 13-7 Nephropedia Template TP {{tp|p=25178879|t=2014. Host-iron assimilation: pathogenesis and novel therapies of mucormycosis |pdf=|usr=}}{{25178879}} gab.com Text Host-iron assimilation: pathogenesis and novel therapies of mucormycosis JO: Mycoses http://www.kidney.de/pget.php?&tw=1&pmid=25178879 #FOAvip Mucormycosis is a fungal infection caused by organisms belonging to the order Mucorales. Although considered uncommon, mucormycosis has been steadily increasing in incidents for the last two decades. Mortality of the disease is unacceptably high despite antifungal therapy and surgical interventions. The lack of understanding of the pathogenesis of the disease and the absence of rapid diagnostic assay contribute to the poor prognosis of mucormycosis. The hyper susceptibility of patients with elevated available serum iron points to the critical role of the ability of Mucorales to acquire host iron as a critical virulence factor. Specifically patients with deferoxamine-therapy, hyperglycaemic with or without ketoacidosis, or other forms of acidosis are uniquely predisposed to mucormycosis. In this review, we discuss the molecular mechanisms of infection in these patient categories in an attempt to identify novel therapies for a disease with poor prognosis. Emphasis on the effect of glucose and free iron on host?pathogen interactions are also covered. Twit Text FOAVip Host-iron assimilation: pathogenesis and novel therapies of mucormycosis ????Mycoses http://www.kidney.de/pget.php?&tw=1&pmid=25178879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25178879 #FOAvip English Wikipedia <ref>{{Cite pmid|25178879}}</ref> Host-iron assimilation: pathogenesis and novel therapies of mucormycosis #MMPMID25178879 Ibrahim AS Mycoses 2014[Dec]; 57 (0 3): 13-7 PMID25178879show ga Mucormycosis is a fungal infection caused by organisms belonging to the order Mucorales. Although considered uncommon, mucormycosis has been steadily increasing in incidents for the last two decades. Mortality of the disease is unacceptably high despite antifungal therapy and surgical interventions. The lack of understanding of the pathogenesis of the disease and the absence of rapid diagnostic assay contribute to the poor prognosis of mucormycosis. The hyper susceptibility of patients with elevated available serum iron points to the critical role of the ability of Mucorales to acquire host iron as a critical virulence factor. Specifically patients with deferoxamine-therapy, hyperglycaemic with or without ketoacidosis, or other forms of acidosis are uniquely predisposed to mucormycosis. In this review, we discuss the molecular mechanisms of infection in these patient categories in an attempt to identify novel therapies for a disease with poor prognosis. Emphasis on the effect of glucose and free iron on host?pathogen interactions are also covered. äHost-iron assimilation: pathogenesis and novel therapies of mucormycos(epmc).pdf DeepDyve Pubget Overpricing