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10.2147/CMAR.S85351 http://scihub22266oqcxt.onion/10.2147/CMAR.S85351 C4461120!4461120!26082661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Manag+Res 2015 ; 7 (ä): 145-51 Nephropedia Template TP {{tp|p=26082661|t=2015. New developments in the treatment of peripheral T-cell lymphoma ? role of Belinostat |pdf=|usr=}}{{26082661}} gab.com Text New developments in the treatment of peripheral T-cell lymphoma role of Belinostat JO: Cancer Manag Res http://www.kidney.de/pget.php?&tw=1&pmid=26082661 #FOAvip Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of rare malignancies that with the exception of anaplastic lymphoma kinase expressing anaplastic large cell lymphoma, share a poor outcome after standard (eg, anthracycline-based) chemotherapy. Most patients are either refractory to initial therapy or eventually relapse. Randomized studies for relapsed/refractory PTCL are not available, however, recently published data show that conventional chemotherapy has very limited efficacy in the salvage setting. Thus, novel drugs are urgently needed to improve the outcome in this setting. Belinostat, a pan-histone deacetylase inhibitor, has demonstrated meaningful efficacy and a favorable toxicity profile in two single-arm Phase II trials on 153 patients with relapsed/refractory PTCL. The conclusive results led to an accelerated approval by the US Food and Drug Administration. The present review summarizes the clinical data available for belinostat, its current role, and future perspectives. Twit Text FOAVip New developments in the treatment of peripheral T-cell lymphoma role of Belinostat ????Cancer Manag Res http://www.kidney.de/pget.php?&tw=1&pmid=26082661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26082661 #FOAvip English Wikipedia <ref>{{Cite pmid|26082661}}</ref> New developments in the treatment of peripheral T-cell lymphoma ? role of Belinostat #MMPMID26082661 Reimer P Cancer Manag Res 2015[]; 7 (ä): 145-51 PMID26082661show ga Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of rare malignancies that with the exception of anaplastic lymphoma kinase expressing anaplastic large cell lymphoma, share a poor outcome after standard (eg, anthracycline-based) chemotherapy. Most patients are either refractory to initial therapy or eventually relapse. Randomized studies for relapsed/refractory PTCL are not available, however, recently published data show that conventional chemotherapy has very limited efficacy in the salvage setting. Thus, novel drugs are urgently needed to improve the outcome in this setting. Belinostat, a pan-histone deacetylase inhibitor, has demonstrated meaningful efficacy and a favorable toxicity profile in two single-arm Phase II trials on 153 patients with relapsed/refractory PTCL. The conclusive results led to an accelerated approval by the US Food and Drug Administration. The present review summarizes the clinical data available for belinostat, its current role, and future perspectives. äNew developments in the treatment of peripheral T-cell lymphoma ? role(epmc).pdf DeepDyve Pubget Overpricing