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10.2147/DDDT.S61436 http://scihub22266oqcxt.onion/10.2147/DDDT.S61436 C4461093!4461093 !26082619     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26082619 &cmd=llinks): Failed to open stream: HTTP request failed! 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Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections |pdf=|usr=}}{{26082619 }} gab.com Text Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26082619 #FOAvip Drug-resistant pathogens have gained a foothold especially in the most vulnerable patient populations, hospitalized and immunocompromised individuals. Furthermore, extended-spectrum ?-lactamase and carbapenemase-producing organisms are finding their way even into the community, with patients presenting to the hospital with established colonization and infection with resistant Enterobacteriaceae in particular. Recently, a novel antipseudomonal cephalosporin in combination with an established Class A ?-lactamase inhibitor, ceftolozane/tazobactam has been approved by the FDA for use in the treatment of complicated urinary tract infections and complicated intra-abdominal infections. Ceftolozane is a uniquely potent antipseudomonal cephalosporin because of its high affinity for the penicillin-binding proteins of Pseudomonas aeruginosa, its low affinity for the intrinsic Class C ?-lactamases of P. aeruginosa, its ability to enter P. aeruginosa through the outer membrane without the utilization of OprD protein, and the fact that it is not a substrate of the often upregulated MexAB/OprM efflux system of P. aeruginosa. The biological chemistry, pharmacokinetics/pharmacodynamics, microbiologic spectrum, and clinical trials that led to the approval of ceftolozane is reviewed. A discussion regarding its potential role in the treatment of complicated intra-abdominal infections and other infectious disease syndromes associated with drug-resistant pathogens follows. Twit Text FOAVip Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26082619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26082619 #FOAvip English Wikipedia <ref>{{Cite pmid|26082619 }}</ref> Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections #MMPMID26082619 Skalweit MJ Drug Des Devel Ther 2015[]; 9 (ä): 2919-25 PMID26082619 show ga Drug-resistant pathogens have gained a foothold especially in the most vulnerable patient populations, hospitalized and immunocompromised individuals. Furthermore, extended-spectrum ?-lactamase and carbapenemase-producing organisms are finding their way even into the community, with patients presenting to the hospital with established colonization and infection with resistant Enterobacteriaceae in particular. Recently, a novel antipseudomonal cephalosporin in combination with an established Class A ?-lactamase inhibitor, ceftolozane/tazobactam has been approved by the FDA for use in the treatment of complicated urinary tract infections and complicated intra-abdominal infections. Ceftolozane is a uniquely potent antipseudomonal cephalosporin because of its high affinity for the penicillin-binding proteins of Pseudomonas aeruginosa, its low affinity for the intrinsic Class C ?-lactamases of P. aeruginosa, its ability to enter P. aeruginosa through the outer membrane without the utilization of OprD protein, and the fact that it is not a substrate of the often upregulated MexAB/OprM efflux system of P. aeruginosa. The biological chemistry, pharmacokinetics/pharmacodynamics, microbiologic spectrum, and clinical trials that led to the approval of ceftolozane is reviewed. A discussion regarding its potential role in the treatment of complicated intra-abdominal infections and other infectious disease syndromes associated with drug-resistant pathogens follows. |Anti-Bacterial Agents/*therapeutic use [MESH] |Cephalosporins/*therapeutic use [MESH] |Drug Approval [MESH] |Drug Resistance, Bacterial [MESH] |Humans [MESH] |Intraabdominal Infections/*drug therapy/microbiology [MESH] |Penicillanic Acid/*analogs & derivatives/therapeutic use [MESH] |Tazobactam [MESH] |United States [MESH]Profile of ceftolozane/tazobactam and its potential in the treatment o(epmc).pdf DeepDyve Pubget Overpricing