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10.3389/fendo.2015.00096 http://scihub22266oqcxt.onion/10.3389/fendo.2015.00096 C4460803!4460803!26106367     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Endocrinol+(Lausanne) 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26106367|t=2015. Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors |pdf=|usr=}}{{26106367}} gab.com Text Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors JO: Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26106367 #FOAvip Adrenocortical tumors (ACTs) are typically unilateral and can be classified as benign adrenocortical adenomas (ACAs) or malignant adrenocortical cancers (ACCs). In rare cases, tumors may occur in both adrenal glands as micronodular hyperplasia (primary pigmented nodular adrenal dysplasia) or as macronodular hyperplasia (primary bilateral macronodular adrenal hyperplasia, PBMAH). The study of certain tumor predisposition syndromes has improved our understanding of sporadic ACTs. Most ACAs are associated with abnormalities of the cAMP signaling pathway, whereas most ACCs are linked to alterations in IGF2, TP53, or the Wnt/?catenin pathways. Over the past year, single-nucleotide polymorphism array technology and next-generation sequencing have identified novel genetic alterations in ACTs that shed new light on the molecular mechanisms of oncogenesis. Among these are somatic mutations of PKA catalytic subunit alpha gene (PRKACA) in ACA, germline, and somatic mutations of armadillo repeat containing 5 gene (ARMC5) in primary bilateral macronodular adrenal hyperplasia and somatic alterations of the E3 ubiquitin ligase gene ZNRF3 in ACC. This review focuses on the recent discoveries and their diagnostic, prognostic, and therapeutic implications. Twit Text FOAVip Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors ????Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=26106367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26106367 #FOAvip English Wikipedia <ref>{{Cite pmid|26106367}}</ref> Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors #MMPMID26106367 Drougat L; Omeiri H; Lefèvre L; Ragazzon B Front Endocrinol (Lausanne) 2015[]; 6 (ä): ä PMID26106367show ga Adrenocortical tumors (ACTs) are typically unilateral and can be classified as benign adrenocortical adenomas (ACAs) or malignant adrenocortical cancers (ACCs). In rare cases, tumors may occur in both adrenal glands as micronodular hyperplasia (primary pigmented nodular adrenal dysplasia) or as macronodular hyperplasia (primary bilateral macronodular adrenal hyperplasia, PBMAH). The study of certain tumor predisposition syndromes has improved our understanding of sporadic ACTs. Most ACAs are associated with abnormalities of the cAMP signaling pathway, whereas most ACCs are linked to alterations in IGF2, TP53, or the Wnt/?catenin pathways. Over the past year, single-nucleotide polymorphism array technology and next-generation sequencing have identified novel genetic alterations in ACTs that shed new light on the molecular mechanisms of oncogenesis. Among these are somatic mutations of PKA catalytic subunit alpha gene (PRKACA) in ACA, germline, and somatic mutations of armadillo repeat containing 5 gene (ARMC5) in primary bilateral macronodular adrenal hyperplasia and somatic alterations of the E3 ubiquitin ligase gene ZNRF3 in ACC. This review focuses on the recent discoveries and their diagnostic, prognostic, and therapeutic implications. äNovel Insights into the Genetics and Pathophysiology of Adrenocortical(epmc).pdf DeepDyve Pubget Overpricing