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10.1146/annurev-animal-031412-103715 http://scihub22266oqcxt.onion/10.1146/annurev-animal-031412-103715 C4460601!4460601!25387017     free     free     free       Annu+Rev+Anim+Biosci 2013 ; 1 (ä): 203-19 Nephropedia Template TP {{tp|p=25387017|t=2013. Genetically Engineered Pig Models for Human Diseases |pdf=|usr=}}{{25387017}} gab.com Text Genetically Engineered Pig Models for Human Diseases JO: Annu Rev Anim Biosci http://www.kidney.de/pget.php?&tw=1&pmid=25387017 #FOAvip Although pigs are used widely as models of human disease, their utility as models has been enhanced by genetic engineering. Initially, transgenes were added randomly to the genome, but with the application of homologous recombination, zinc finger nucleases, and transcription activator-like effector nuclease (TALEN) technologies, now most any genetic change that can be envisioned can be completed. To date these genetic modifications have resulted in animals that have the potential to provide new insights into human diseases for which a good animal model did not exist previously. These new animal models should provide the preclinical data for treatments that are developed for diseases such as Alzheimer's disease, cystic fibrosis, retinitis pigmentosa, spinal muscular atrophy, diabetes, and organ failure. These new models will help to uncover aspects and treatments of these diseases that were otherwise unattainable. The focus of this review is to describe genetically engineered pigs that have resulted in models of human diseases. Twit Text FOAVip Genetically Engineered Pig Models for Human Diseases ????Annu Rev Anim Biosci http://www.kidney.de/pget.php?&tw=1&pmid=25387017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25387017 #FOAvip English Wikipedia <ref>{{Cite pmid|25387017}}</ref> Genetically Engineered Pig Models for Human Diseases #MMPMID25387017 Prather RS; Lorson M; Ross JW; Whyte JJ; Walters E Annu Rev Anim Biosci 2013[Jan]; 1 (ä): 203-19 PMID25387017show ga Although pigs are used widely as models of human disease, their utility as models has been enhanced by genetic engineering. Initially, transgenes were added randomly to the genome, but with the application of homologous recombination, zinc finger nucleases, and transcription activator-like effector nuclease (TALEN) technologies, now most any genetic change that can be envisioned can be completed. To date these genetic modifications have resulted in animals that have the potential to provide new insights into human diseases for which a good animal model did not exist previously. These new animal models should provide the preclinical data for treatments that are developed for diseases such as Alzheimer's disease, cystic fibrosis, retinitis pigmentosa, spinal muscular atrophy, diabetes, and organ failure. These new models will help to uncover aspects and treatments of these diseases that were otherwise unattainable. The focus of this review is to describe genetically engineered pigs that have resulted in models of human diseases. äGenetically Engineered Pig Models for Human Diseases (epmc).pdf DeepDyve Pubget Overpricing