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10.1016/j.jaci.2015.03.004 http://scihub22266oqcxt.onion/10.1016/j.jaci.2015.03.004 C4460579!4460579!26051952     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26051952&cmd=llinks): Failed to open stream: HTTP request failed! 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Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2 0) identify histologic and molecular correlates of the key clinical features of disease |pdf=|usr=}}{{26051952}} gab.com Text Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2 0) identify histologic and molecular correlates of the key clinical features of disease JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051952 #FOAvip Background: The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS® v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastrointestinal reflux disease (GERD), nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear. Objective: The purpose of this study was to determine if clinical features of EoE, measured through the PEESS® v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens. Methods: We systematically recruited treated and untreated, pediatric patients with EoE (aged 2?18 years) and examined parent proxy?reported symptoms using the PEESS® v2.0. Clinical symptomology was collected by questionnaire. Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells. Molecular features were assessed by the EoE Diagnostic Panel (94 EoE-related gene transcripts). Associations between domain scores and clinical symptoms and biologic features were analyzed using Wilcoxon Rank Sum and Spearman correlation. Results: The PEESS® v2.0 domains correlated to specific parent-reported symptoms: dysphagia (p = 0.0012), GERD (p = 0.0001), and nausea/vomiting (p < 0.0001). Pain correlated with multiple symptoms (p < 0.0005). Dysphagia correlated most strongly with overall histopathology, particularly in the proximal esophagus (p ? 0.0049). Markers of esophageal activity (EPX) were significantly associated with dysphagia (strongest r = .37; p = 0.02). Eosinophil levels were more associated with pain (r = 0.27; p=0.06) than for dysphagia (r = 0.24; p = 0.13). The dysphagia domain correlated the most with esophageal gene transcript levels, predominantly with mast cell?specific genes. Conclusion: We have 1) established a validated, parent proxy?report measure for pediatric EoE ? the PEESS® v2.0; 2) verified that parent-proxy effectively captures symptoms; 3) determined that the dysphagia domain most closely aligns with symptoms and tissue-based molecular biomarkers; 4) established that symptoms correlate EPX staining; and 5) observed association between mast cells and dysphagia. Twit Text FOAVip Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2 0) identify histologic and molecular correlates of the key clinical features of disease ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26051952 #FOAvip English Wikipedia <ref>{{Cite pmid|26051952}}</ref> Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2 0) identify histologic and molecular correlates of the key clinical features of disease #MMPMID26051952 Martin LJ; Franciosi JP; Collins MH; Abonia JP; Lee JJ; Hommel KA; Varni JW; Grotjan JT; Eby M; He H; Marsolo K; Putnam PE; Garza JM; Kaul A; Wen T; Rothenberg ME J Allergy Clin Immunol 2015[Jun]; 135 (6): 1519-1528.e8 PMID26051952show ga Background: The Pediatric Eosinophilic Esophagitis Symptom Score (PEESS® v2.0) measures patient-relevant outcomes. However, whether patient-identified domains (dysphagia, gastrointestinal reflux disease (GERD), nausea/vomiting, and pain) align with clinical symptomology and histopathologic and molecular features of eosinophilic esophagitis (EoE) is unclear. Objective: The purpose of this study was to determine if clinical features of EoE, measured through the PEESS® v2.0, associate with histopathologic and molecular features of EoE. This represents a novel approach for analysis of allergic diseases, given the availability of allergic tissue biopsy specimens. Methods: We systematically recruited treated and untreated, pediatric patients with EoE (aged 2?18 years) and examined parent proxy?reported symptoms using the PEESS® v2.0. Clinical symptomology was collected by questionnaire. Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells. Molecular features were assessed by the EoE Diagnostic Panel (94 EoE-related gene transcripts). Associations between domain scores and clinical symptoms and biologic features were analyzed using Wilcoxon Rank Sum and Spearman correlation. Results: The PEESS® v2.0 domains correlated to specific parent-reported symptoms: dysphagia (p = 0.0012), GERD (p = 0.0001), and nausea/vomiting (p < 0.0001). Pain correlated with multiple symptoms (p < 0.0005). Dysphagia correlated most strongly with overall histopathology, particularly in the proximal esophagus (p ? 0.0049). Markers of esophageal activity (EPX) were significantly associated with dysphagia (strongest r = .37; p = 0.02). Eosinophil levels were more associated with pain (r = 0.27; p=0.06) than for dysphagia (r = 0.24; p = 0.13). The dysphagia domain correlated the most with esophageal gene transcript levels, predominantly with mast cell?specific genes. Conclusion: We have 1) established a validated, parent proxy?report measure for pediatric EoE ? the PEESS® v2.0; 2) verified that parent-proxy effectively captures symptoms; 3) determined that the dysphagia domain most closely aligns with symptoms and tissue-based molecular biomarkers; 4) established that symptoms correlate EPX staining; and 5) observed association between mast cells and dysphagia. äPediatric Eosinophilic Esophagitis Symptom Scores (PEESS® v2 0) identi(epmc).pdf DeepDyve Pubget Overpricing