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10.1073/pnas.1411264111 http://scihub22266oqcxt.onion/10.1073/pnas.1411264111 C4460512!4460512!25378702     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (22): 6863-70 Nephropedia Template TP {{tp|p=25378702|t=2015. Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription |pdf=|usr=}}{{25378702}} gab.com Text Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25378702 #FOAvip Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ?24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional?translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear ?hubs? of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control. Twit Text FOAVip Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25378702 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378702 #FOAvip English Wikipedia <ref>{{Cite pmid|25378702}}</ref> Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription #MMPMID25378702 Aguilar-Arnal L; Sassone-Corsi P Proc Natl Acad Sci U S A 2015[Jun]; 112 (22): 6863-70 PMID25378702show ga Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ?24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional?translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear ?hubs? of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control. äChromatin landscape and circadian dynamics: Spatial and temporal organ(epmc).pdf DeepDyve Pubget Overpricing